| Effect of Low-Dose Amitriptyline on Autonomic Functions and Peripheral Blood Flow in Fibromyalgia: A Pilot Study. | |
| | |
MedLine Citation:
|
PMID: 22142408 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Objective. Amitriptyline (10-50 mg) is the most common drug prescribed for the treatment of fibromyalgia. Amitriptyline influences the autonomic nervous system, as is well known; fibromyalgia is also associated with dysautonomia. The present preliminary study was designed to observe the effects of amitriptyline prescribed in a low dose (10 mg) on the autonomic function tests and blood flow measurements in well-diagnosed patients with fibromyalgia. Methodology. Amitriptyline (10 mg) was prescribed for 3 months to 21 female patients with fibromyalgia. A standard battery of noninvasive autonomic function tests comprising of lying to standing test, hand grip test, cold pressor test, deep breathing test, and Valsalva maneuver was performed both before and after amitriptyline therapy to study the autonomic reactivity of the patients with fibromyalgia. Heart rate variability analysis was done to quantify autonomic tone (activity). Blood flow measurement around the knee joint was performed using impedance plethysmography technique. The patients were also assessed for 10 major clinical symptoms of primary fibromyalgia and state and trait anxiety (state and trait anxiety inventory) at both instances. Results. No significant changes in autonomic activity (tone) and reactivity were observed after amitriptyline therapy. Clinical symptom score and anxiety scores (both state and trait) decreased significantly from the pretreatment values. Blood flow measurement showed significant improvement in blood flow index values at the affected sites after amitriptyline therapy. Conclusion. Amitriptyline therapy (10 mg for 3 months) increases blood flow to the affected sites. It does not affect autonomic tone and reactivity in the patients with fibromyalgia. |
| | |
Authors:
|
Poorvi Kulshreshtha; Rajiva Gupta; Raj Kumar Yadav; Ramesh Lal Bijlani; Kishore Kumar Deepak |
Related Documents
:
|
21775798 - The effect of ventricular assist devices on cerebral blood flow and blood pressure frac... 13129778 - Rapid degradation of the mycotoxin patulin in man quantified by stable isotope dilution... 22194278 - Impact of clopidogrel on bleeding complications and survival in off-pump coronary arter... 16026338 - Polymorphism at the porcine dominant white/kit locus influence coat colour and peripher... 21761188 - A positron emission tomography approach to visualize flow perfusion in hollow-fiber mem... 11909348 - Longitudinal flow of protons from (2-8)a gev central au+au collisions. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
|
Title: Pain medicine (Malden, Mass.) Volume: - ISSN: 1526-4637 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100894201 Medline TA: Pain Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Wiley Periodicals, Inc. |
Affiliation:
|
Departments of Physiology Medicine, All India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Asian Consensus Report on Functional Dyspepsia.
Next Document: Bioadhesiveness and efficient mechanotransduction stimuli synergistically provided by bacterial incl...