| Effect of the loading dose of magnesium sulfate (MgSO4) on the parameters of Doppler flow velocity in the uterine, umbilical and middle cerebral arteries in severe preeclampsia. | |
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MedLine Citation:
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PMID: 19891531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate Doppler velocimetry parameters (resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio) of maternal-fetal circulation before and after magnesium sulfate administration in pregnant women with severe preeclampsia. METHODS: A prospective observational cohort analysis of 40 women with severe preeclampsia was performed. Doppler ultrasonography scans were performed before and 20 minutes after intravenous administration of magnesium sulfate. Maternal parameters such as heart rate, and systolic, diastolic and mean arterial pressure were recorded. Doppler flow velocity parameters (RI, PI and S/D ratio) were evaluated in the uterine, umbilical and middle cerebral arteries. The different mean values obtained before and after magnesium sulphate were analyzed using the paired t-test. RESULTS: There was a statistically significant increase in mean maternal heart rate and a statistically significant decrease in systolic, diastolic and mean maternal blood pressure before and after administration of magnesium sulphate (p < 0.001). Resistance index decreased in the umbilical (p = 0.003; 95% CI: 0.008 - 0.03) and middle cerebral artery (p = 0.001; 95% CI: 0.01 - 0.05) and in both uterine arteries. Likewise, there was a significant reduction in the PI and S/D ratio in all the arteries assessed. CONCLUSIONS: Maternal administration of intravenous magnesium sulfate in preeclampsia leads to an increase in maternal heart rate and a decrease in systolic, diastolic and mean arterial blood pressure. A reduction in the resistance index, pulsatility index and S/D ratio was recorded in the uterine, umbilical and cerebral arteries. |
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Authors:
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Alex Sandro Rolland Souza; Melania Maria Ramos Amorim; Isabela Cristina A N C Coutinho; Marcelo Marques de Souza Lima; Carlos Noronha Neto; Jos? Natal Figueroa |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 29 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-06-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
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Languages: eng Pagination: 123-34 Citation Subset: IM |
Affiliation:
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Instituto de Medicina Integral Professor Fernando Figueira-IMIP, Recife, Brazil. alexrolland@uol.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / administration & dosage* Blood Flow Velocity / drug effects Female Humans Magnesium Sulfate / administration & dosage* Middle Cerebral Artery / drug effects, ultrasonography Pre-Eclampsia / drug therapy*, physiopathology, ultrasonography Pregnancy Prospective Studies Ultrasonography, Prenatal Umbilical Arteries / drug effects, ultrasonography Uterine Artery / drug effects, ultrasonography Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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