Document Detail


Effect of Levovist on splanchnic hemodynamics in cirrhotic patients.
MedLine Citation:
PMID:  12754063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was aimed to assess the effect of Levovist on Doppler parameters of splanchnic hemodynamics. A total of 12 patients with cirrhosis and 12 healthy subjects underwent Doppler ultrasound (US) examination of the portal vein and of the hepatic, splenic and superior mesenteric arteries before, 5 to 8 and 12 to 15 min after the start of an 8-min long IV infusion of 2.5 g of Levovist. Mean velocity and mean diameter were calculated for the portal vein. Resistance index was determined for the arteries. A significant increase of resistance index was observed in the hepatic (0.80 +/- 0.07 vs. 0.71 +/- 0.06; p < 0.01) and splenic arteries (0.72 +/- 0.06 vs. 0.64 +/- 0.06; p < 0.01) 5 to 8 min after contrast agent injection in patients with cirrhosis, but not in controls. Neither portal vein diameter nor portal flow mean velocity changed during the test in both controls and cirrhotic patients. This effect might be related to a selective trapping of microbubbles in the altered hepatic and splenic microvasculature in patients with cirrhosis rather than being artefactual. It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase.
Authors:
Stefano Gaiani; Carla Serra; Fabio Piscaglia; Natascia Celli; Leonardo Rasciti; Mario Miglioli; Luigi Bolondi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  29     ISSN:  0301-5629     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-09-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
Affiliation:
Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi di Bologna, Bologna, Italy. sgaiani@med.unibo.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Contrast Media / pharmacology*
Female
Hemodynamics / drug effects
Hepatic Artery / drug effects,  physiopathology,  ultrasonography
Humans
Liver Cirrhosis / physiopathology*,  ultrasonography
Male
Middle Aged
Polysaccharides / pharmacology*
Splanchnic Circulation / drug effects*
Splenic Artery / drug effects,  physiopathology,  ultrasonography
Ultrasonography, Doppler
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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