| Effect of leukoreduction on transfusion-induced inflammation in dogs. | |
| | |
MedLine Citation:
|
PMID: 20666981 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: Removal of leukocytes (LR) has been shown to eliminate or attenuate many of the adverse effects of transfusion in experimental animals and humans. HYPOTHESIS/OBJECTIVES: Transfusion of stored packed red blood cells (pRBCs) is associated with an inflammatory response in dogs and prestorage LR attenuates the inflammatory response. ANIMALS: Thirteen random-source, clinically healthy, medium and large breed dogs. METHODS: Experimental study. On day 0, animals were examined and baseline blood samples were collected for analysis. Whole blood was then collected for processing with and without LR, and stored as pRBC. Twenty-one days later, stored pRBCs were transfused back to the donor. Blood samples were collected before and 1 and 3 days after transfusion. RESULTS: In the dogs that received non-LR pRBCs (n = 6) there was a significant increase from baseline in white blood cell count from a mean (SD) of 8.20 (2.74) to 13.95 (4.60) × 10(3) cells/μL (P < .001) and in segmented neutrophil count from a mean (SD) of 5.76 (2.70) to 11.91 (4.71) × 10(3) cells/μL (P < .001). There were also significant increases in fibrinogen from a mean (SD) of 129.7 (24.2) to 268.6 (46.7) mg/dL (P < .001) and C-reactive protein from a mean (SD) of 1.9 (2.1) to 78.3 (39.3) μg/mL (P < .001). There was no significant increase from baseline in any of the markers in the dogs that received LR pRBC (n = 5). CONCLUSIONS AND CLINICAL IMPORTANCE: There is a profound inflammatory response to transfusion in normal dogs, which is eliminated by LR of the pRBC units. |
| | |
Authors:
|
M A McMichael; S A Smith; A Galligan; K S Swanson; T M Fan |
Publication Detail:
|
Type: Journal Article Date: 2010-07-28 |
Journal Detail:
|
Title: Journal of veterinary internal medicine / American College of Veterinary Internal Medicine Volume: 24 ISSN: 0891-6640 ISO Abbreviation: J. Vet. Intern. Med. Publication Date: 2010 Sep-Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8708660 Medline TA: J Vet Intern Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1131-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 by the American College of Veterinary Internal Medicine. |
Affiliation:
|
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA. mmcm@illinois.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Congenital Ureteral Ectopia in Continent and Incontinent-Related Entlebucher Mountain Dogs: 13 Cases...
Next Document: Ultrasonography Criteria for Differentiating ACTH Dependency from ACTH Independency in 47 Dogs with ...