| Effect of LPS on the oxidative metabolism of peritoneal and spleen cells from LPS sensitive and resistant mice. | |
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MedLine Citation:
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PMID: 6530697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of LPS on peritoneal and spleen cell oxidative metabolism was investigated in LPS sensitive (C57BL/6) and LPS resistant (C3H/HeJ) mice following intraperitoneal or subcutaneous injection, by measurement of chemiluminescent (CL) responses to latex particles. In C57BL/6 mice, LPS induced a marked increase in peritoneal and spleen cell CL responses, regardless of the route of injection. On the 2nd day, the effect of LPS on peritoneal cells could be fully explained by an inflammatory reaction, while on the 4th day it could be related to an "activated state" of peritoneal macrophages. In contrast, such an in vivo effect of LPS in peritoneal or spleen cell CL responses was not found in C3H/HeJ mice except on the 2nd day following the injection and with the highest LPS dosage and could be totally due to the LPS induced inflammatory reaction. In vitro studies showed that extremely low concentration of LPS increased CL response capacities of C57BL/6 spleen cell to latex particles. In contrast, CL responses from C3H/HeJ spleen cells remained unaffected by LPS except when submitted to concentrations which proved toxic for the sensitive strain CL producing cells. These results lend additional evidence for the involvement of reactive oxygen species (ROS) in the metabolic consequences of LPS-induced macrophage activation. |
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Authors:
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M N Feuillet-Fieux; R M Golub; A T Nguyen; P Zamfirescu; B Descamps-Latscha |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Journal of clinical & laboratory immunology Volume: 15 ISSN: 0141-2760 ISO Abbreviation: J Clin Lab Immunol Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1985-04-26 Completed Date: 1985-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7808987 Medline TA: J Clin Lab Immunol Country: ITALY |
Other Details:
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Languages: eng Pagination: 155-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / pathology Lipopolysaccharides / pharmacology* Luminescent Measurements Macrophage Activation / drug effects Male Mice Mice, Inbred C3H Mice, Inbred C57BL Neutrophils / metabolism Oxygen / metabolism Phagocytes / drug effects*, metabolism Spleen / drug effects*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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