| Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients. | |
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MedLine Citation:
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PMID: 22986485 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Apolipoprotein B-48 (Apo B-48) is a constituent of chylomicrons and chylomicron remnants, and is thought to be one of the risk factors for atherosclerosis. We evaluated the effect of L-thyroxine (L-T(4)) replacement on serum Apo B-48 levels in patients with primary hypothyroidism. Eighteen patients with overt hypothyroidism (OH) and 18 patients with subclinical hypothyroidism (SH) participated in the study. The lipid profiles, including Apo B-48, were measured in patients with hypothyroidism before and 3 months after L-T(4) replacement. After L-T(4) replacement, the serum concentrations of all lipoproteins, exclusive of lipoprotein (a) [Lp(a)], were significantly decreased in patients with OH. In patents with SH, the serum levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), remnant-like particle cholesterol (RLP-C), apolipoprotein B (Apo B), and Apo B-48 decreased significantly after L-T(4) replacement. The serum levels of triglycerides (TG), HDL-C, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (Apo A1), and Lp(a) did not change significantly. In all 36 patients, the reduction in the Apo B-48 levels correlated significantly with the reduction in TSH levels (r = 0.39, P<0.05). This study showed clearly that L-T(4) replacement might reduce serum levels of Apo B-48 in both OH and SH patients. Such altered serum levels of Apo B-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism. |
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Authors:
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Mitsuru Ito; Akira Kitanaka; Takeshi Arishima; Takumi Kudo; Eijun Nishihara; Sumihisa Kubota; Nobuyuki Amino; Tetsuya Hiraiwa; Toshiaki Hanafusa; Akira Miyauchi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-15 |
Journal Detail:
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Title: Endocrine journal Volume: - ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Kuma Hospital, Kobe 650-0011, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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