Document Detail


Effect of L-thyroxine replacement on apolipoprotein B-48 in overt and subclinical hypothyroid patients.
MedLine Citation:
PMID:  22986485     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Apolipoprotein B-48 (Apo B-48) is a constituent of chylomicrons and chylomicron remnants, and is thought to be one of the risk factors for atherosclerosis. We evaluated the effect of L-thyroxine (L-T(4)) replacement on serum Apo B-48 levels in patients with primary hypothyroidism. Eighteen patients with overt hypothyroidism (OH) and 18 patients with subclinical hypothyroidism (SH) participated in the study. The lipid profiles, including Apo B-48, were measured in patients with hypothyroidism before and 3 months after L-T(4) replacement. After L-T(4) replacement, the serum concentrations of all lipoproteins, exclusive of lipoprotein (a) [Lp(a)], were significantly decreased in patients with OH. In patents with SH, the serum levels of total cholesterol (TC), non-high-density lipoprotein cholesterol (non-HDL-C), remnant-like particle cholesterol (RLP-C), apolipoprotein B (Apo B), and Apo B-48 decreased significantly after L-T(4) replacement. The serum levels of triglycerides (TG), HDL-C, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (Apo A1), and Lp(a) did not change significantly. In all 36 patients, the reduction in the Apo B-48 levels correlated significantly with the reduction in TSH levels (r = 0.39, P<0.05). This study showed clearly that L-T(4) replacement might reduce serum levels of Apo B-48 in both OH and SH patients. Such altered serum levels of Apo B-48 in patients with OH and SH may be related to the disturbed metabolism of chylomicron remnants in patients with hypothyroidism.
Authors:
Mitsuru Ito; Akira Kitanaka; Takeshi Arishima; Takumi Kudo; Eijun Nishihara; Sumihisa Kubota; Nobuyuki Amino; Tetsuya Hiraiwa; Toshiaki Hanafusa; Akira Miyauchi
Related Documents :
23718655 - Assessment of a commercially available point-of-care assay for the measurement of bovin...
23087555 - Comparison of serum creatinine and spot urine interleukin-18 levels following radiocont...
23115735 - Immunologic evaluation of ofloxacin hypersensitivity.
24386995 - Phytoandrogenic properties of eurycoma longifolia as natural alternative to testosteron...
10084465 - Salbutamol metered-dose inhaler with spacer for hyperkalemia: how fast? how safe?
3377265 - Serum copper, magnesium, zinc, calcium, and potassium changes following acute myocardia...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-15
Journal Detail:
Title:  Endocrine journal     Volume:  -     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Kuma Hospital, Kobe 650-0011, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Correlation between Protective Immunity to ?-Synuclein Aggregates, Oxidative Stress and Inflammation...
Next Document:  Essential roles of growth hormone (GH) and insulin-like growth factor-I (IGF-I) in the liver [Review...