| Effect of L-arginine/nitric oxide pathway on MPP(+)-induced cell injury in the striatum of rats. | |
| | |
MedLine Citation:
|
PMID: 8019760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. Protection against 1-methyl-4-phenylpyridinium ion (MPP+) neurotoxicity by two nitric oxide-related compounds, N omega-nitro-L-arginine (L-NOARG) and L-arginine, was studied in the corpus striatum by means of two MPP+ perfusions separated by 24 h. Dopamine extracellular output after the second MPP+ (1, 5 and 10 mM) perfusion was considered as an index of the dopaminergic neurone damage produced by the first MPP+ (1, 5 and 10 mM) perfusion. 2. L-NOARG, systemically administered (10 mg kg-1, i.p., every 12 h for 4 days), failed to prevent the neurotoxic action of MPP+ (1 and 10 mM). On the contrary, the neurotoxic effect of MPP+ was increased by L-NOARG administration. 3. L-Arginine (10 mM) perfused 2 h before MPP+ perfusion did not protect against the neurotoxic action of high MPP+ concentrations (5 and 10 mM). At the highest MPP+ concentration used (10 mM), the increase in the extracellular output of dopamine after the second MPP+ perfusion was slower in L-arginine-treated rats than in control and L-NOARG-treated rats. 4. When MPP+ (1 mM) was perfused 2 h after L-arginine (10 mM) perfusion, there was a clear protection against MPP+ neurotoxicity. In the second MPP+ (1 mM) perfusion, the increase in the extracellular output of dopamine in L-arginine-treated rats was twice as high as for the control rats. 5. The results indicate that NO may exert a protective mechanism in the presence of a low ambient redox. |
| | |
Authors:
|
M Santiago; A Machado; J Cano |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of pharmacology Volume: 111 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1994 Mar |
Date Detail:
|
Created Date: 1994-08-02 Completed Date: 1994-08-02 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 837-42 Citation Subset: IM |
Affiliation:
|
Departamento de Bioquímica, Facultad de Farmacia, Sevilla, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Methyl-4-phenylpyridinium
/
toxicity* Animals Arginine / analogs & derivatives, metabolism*, therapeutic use* Brain Diseases / chemically induced*, prevention & control* Corpus Striatum / drug effects*, metabolism*, secretion Dialysis Dopamine / secretion Male Nitric Oxide / metabolism* Nitroarginine Perfusion Rats Rats, Wistar Time Factors |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 48134-75-4/1-Methyl-4-phenylpyridinium; 74-79-3/Arginine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential action of (+)-amphetamine on electrically evoked dopamine overflow in rat brain slices ...
Next Document: Central and peripheral actions of the novel kappa-opioid receptor agonist, EMD 60400.