| Effect of L-carnitine on weight loss and body composition of rats fed a hypocaloric diet. | |
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MedLine Citation:
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PMID: 12378044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Several studies have been published in recent years which suggest that L-carnitine supplementation can influence the lipid metabolism in some species and can also affect body composition of growing animals. Only few results are available so far on the effect of L-carnitine supplementation on weight reduction and body composition of animals fed an energy-deficient diet. The aim of this study was therefore to investigate whether L-carnitine supplementation combined with an energy-deficient diet can influence weight development and body composition. METHODS: An experiment was conducted with 36 rats with an initial body weight of about 460 g. One-third of the rats were killed, the remainder were divided into two groups (control group, treated group) and fed a semi synthetic diet at an energy level of about half of the rats' maintenance requirement. The basal diet was essentially carnitine-free. The diet of the treated group was supplemented with L-carnitine (5 g/kg). The feeding period extended over 23 days. Experimental parameters were weight loss, composition of carcass and weights of the fat pads surrounding the kidneys, intestine and testes; several clinico-chemical plasma parameters were also determined. RESULTS: As was to be expected, the rats lost a considerable amount of weight on the energy-reduced diet. At the same time a shift occurred in the ratio of fat to protein in favour of protein in the carcass, leading to a marked reduction of body fat levels and a slight reduction of protein levels. There were, however, no significant differences between the control group and the treated group (with L-carnitine supplementation) with regard to any of these parameters. The clinico-chemical parameters measured in plasma (glucose, triglycerides, total cholesterol, free fatty acids, 3-hydroxybutyric acid) also showed no differences between the groups. CONCLUSIONS: The rat model used here did not show a positive effect of L-carnitine supplementation on weight loss and body composition of rats fed an energy-deficient diet. The animals' endogenous carnitine synthesis was obviously adequate to ensure efficient beta-oxidation of fatty acids during the catabolic phase. |
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Authors:
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Corinna Brandsch; Klaus Eder |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 46 ISSN: 0250-6807 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-10-14 Completed Date: 2003-04-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 205-10 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Institute of Nutritional Sciences, University of Halle, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Body Composition / drug effects* Caloric Restriction* Carnitine / administration & dosage*, blood Cholesterol / blood Dietary Supplements Fatty Acids / blood Male Rats Rats, Sprague-Dawley Time Factors Triglycerides / blood Weight Loss / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids; 0/Triglycerides; 541-15-1/Carnitine; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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