| Effect of L-arginine on the expression of Bcl-2 and Bax in the placenta of fetal growth restriction. | |
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MedLine Citation:
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PMID: 21067292 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective. To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta. Methods. Sixty pregnant women with FGR were randomized to receive conventional treatment alone (control group, n = 30) or in combination with l-arginine (l-arginine group, n = 30). The parameters of fetal growth and development were monitored by B-ultrasound at regular intervals. The newborn birth weight and perinatal outcomes were also documented. Placental tissue was sampled within 10 min after delivery for analysis. The expression of Bcl-2 and Bax in placental tissue was determined by immunohistochemical technique. Results. The fetal growth parameters of biparietal diameter, femur length, and abdominal circumference increased more significantly in l-arginine group than those in control group (p < 0.0l). The cure rate and birth weight in l-arginine group were higher than those in control group (73.3% vs. 43.3%, 2455.20 g vs. 2402.63 g, respectively). The incidence of small for gestational age newborns in l-arginine group was significantly lower than that in control group. Compared with l-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group. Conclusions. l-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development. |
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Authors:
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Su-Fang Shen; Cai-Hong Hua |
Publication Detail:
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Type: Journal Article Date: 2010-11-10 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 24 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 822-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, the Third Hospital Affiliated to Xinxiang Medical College, Xinxiang 453103, Henan Province, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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