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Effect of L-arginine on the expression of Bcl-2 and Bax in the placenta of fetal growth restriction.
MedLine Citation:
PMID:  21067292     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective. To investigate the effect of l-arginine on fetal growth restriction (FGR) in terms of the expression of Bcl-2 and Bax in placenta. Methods. Sixty pregnant women with FGR were randomized to receive conventional treatment alone (control group, n = 30) or in combination with l-arginine (l-arginine group, n = 30). The parameters of fetal growth and development were monitored by B-ultrasound at regular intervals. The newborn birth weight and perinatal outcomes were also documented. Placental tissue was sampled within 10 min after delivery for analysis. The expression of Bcl-2 and Bax in placental tissue was determined by immunohistochemical technique. Results. The fetal growth parameters of biparietal diameter, femur length, and abdominal circumference increased more significantly in l-arginine group than those in control group (p < 0.0l). The cure rate and birth weight in l-arginine group were higher than those in control group (73.3% vs. 43.3%, 2455.20 g vs. 2402.63 g, respectively). The incidence of small for gestational age newborns in l-arginine group was significantly lower than that in control group. Compared with l-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group. Conclusions. l-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.
Authors:
Su-Fang Shen; Cai-Hong Hua
Publication Detail:
Type:  Journal Article     Date:  2010-11-10
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  24     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  822-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, the Third Hospital Affiliated to Xinxiang Medical College, Xinxiang 453103, Henan Province, China.
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