Document Detail

Effect of L-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice.
MedLine Citation:
PMID:  18243372     Owner:  NLM     Status:  MEDLINE    
Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, L-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of L-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with L-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P<0.001) and VEGF serum levels (P<0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.
Carmela Fiorito; Maria Luisa Balestrieri; Ettore Crimi; Alfonso Giovane; Vincenzo Grimaldi; Pellegrino Biagio Minucci; Luigi Servillo; Francesco Paolo D'Armiento; Bartolomeo Farzati; Claudio Napoli
Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2008-02-19
Journal Detail:
Title:  International journal of cardiology     Volume:  126     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  421-3     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Arginine / metabolism*,  pharmacology
Cell Movement / drug effects,  physiology*
Coronary Disease / physiopathology*,  prevention & control
Enzyme-Linked Immunosorbent Assay
Exercise Tolerance / drug effects,  physiology*
Mice, Inbred C57BL
Models, Animal
Physical Conditioning, Animal
Random Allocation
Sensitivity and Specificity
Stem Cells / cytology*,  drug effects,  metabolism
Vascular Endothelial Growth Factor A / blood,  metabolism*
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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