| Effect of L-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice. | |
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MedLine Citation:
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PMID: 18243372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, L-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of L-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with L-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P<0.001) and VEGF serum levels (P<0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion. |
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Authors:
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Carmela Fiorito; Maria Luisa Balestrieri; Ettore Crimi; Alfonso Giovane; Vincenzo Grimaldi; Pellegrino Biagio Minucci; Luigi Servillo; Francesco Paolo D'Armiento; Bartolomeo Farzati; Claudio Napoli |
Publication Detail:
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Type: Letter; Research Support, Non-U.S. Gov't Date: 2008-02-19 |
Journal Detail:
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Title: International journal of cardiology Volume: 126 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-16 Completed Date: 2008-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 421-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Arginine / metabolism*, pharmacology Cell Movement / drug effects, physiology* Coronary Disease / physiopathology*, prevention & control Enzyme-Linked Immunosorbent Assay Exercise Tolerance / drug effects, physiology* Mice Mice, Inbred C57BL Models, Animal Physical Conditioning, Animal Probability Random Allocation Sensitivity and Specificity Stem Cells / cytology*, drug effects, metabolism Vascular Endothelial Growth Factor A / blood, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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