| Effect of L-arginine oral supplementation on response to myocardial infarction in hypercholesterolemic and hypertensive rats. | |
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MedLine Citation:
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PMID: 20087664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The well known metabolic functions of L-arginine have been recently increased with the discovery of its role as the substrate for the synthesis of nitric oxide (NO), which has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of NO are derived in part from dietary sources. It has been reported that supplementation of L-arginine reduces atherosclerosis in rabbits and reduces the arterial pressure in hypertensive rats. Therefore, we investigated the effect of L-arginine supplementation using a group of induced hypercholesterolemic rats and a group of spontaneously hypertensive rats; the infarcted area in cardiac tissue of both groups was measured during the response to myocardial infarction in the ischemia-reperfusion model. Hypercholesterolemic rats supplemented with 170 mg kg(-1) of L-arginine showed a significant (P <or= 0.05) reduction in total cholesterol (25.2%) and LDL (27.8%). Spontaneously hypertensive rats supplemented with L-arginine presented a significant reduction (20.3%) in mean blood pressure (P <or= 0.05). The index infarcted area/total heart area, in both: hypercholesterolemic and hypertensive rats supplemented with L-arginine, showed a significant 36% and 29% of cardio protection (P <or= 0.05) effect, respectively. Dietary supplementation with L-arginine may represent a potentially novel nutritional strategy for the treatment of cardiovascular disease. |
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Authors:
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Verónica Piñeiro; Alicia Ortiz-Moreno; Rosalva Mora-Escobedo; María Dolores Hernández-Navarro; Guillermo Ceballos-Reyes; Germán Chamorro-Cevallos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Plant foods for human nutrition (Dordrecht, Netherlands) Volume: 65 ISSN: 1573-9104 ISO Abbreviation: Plant Foods Hum Nutr Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-18 Completed Date: 2010-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803554 Medline TA: Plant Foods Hum Nutr Country: Netherlands |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Affiliation:
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Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, DF, México. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Arginine / pharmacology, therapeutic use* Blood Pressure / drug effects* Cardiovascular Agents / pharmacology, therapeutic use* Dietary Supplements* Hypercholesterolemia / drug therapy* Hypertension / drug therapy* Male Myocardial Infarction / drug therapy* Myocardium / pathology Nitric Oxide Random Allocation Rats Rats, Inbred SHR Rats, Inbred WKY |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 10102-43-9/Nitric Oxide; 74-79-3/Arginine |
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