| Effect of L-NMMA on postprandial transient lower esophageal sphincter relaxations in healthy volunteers. | |
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MedLine Citation:
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PMID: 11117586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study we showed that nitric oxide (NO) synthesis inhibition by NG-monomethyl-L-arginine (L-NMMA) reduced the number of transient lower esophageal sphincter relaxations (TLESRs) triggered by gastric balloon distention. The role of NO in postprandial TLESRs and gastroesophageal reflux, however, is unknown. Therefore, we studied the effect of L-NMMA on meal-induced TLESRs and reflux episodes with simultaneous recording of esophageal peristalsis, intraesophageal and intragastric pH, and gastric emptying in healthy volunteers. Ingestion of a solid meal resulted in an increase in TLESRs [8.5 (6.3-11.0) 60 min] which was significantly inhibited by L-NMMA [6.0 (4.0-8.8) 60 min, P < 0.05]. In addition, the total number of reflux episodes was reduced. L-NMMA had no effect on intragastric meal distribution and gastric emptying, but attenuated the postprandial increase in intragastric pH. These results confirm the involvement of NO in the neurocircuitry underlying the triggering of TLESRs. The reduction in reflux by L-NMMA has to be confirmed in patients with gastroesophageal reflux disease. NO may be involved in the regulation of gastric acid secretion. |
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Authors:
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D P Hirsch; M M Tiel-Van Buul; G N Tytgat; G E Boeckxstaens |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 45 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-12-14 Completed Date: 2001-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 2069-75 Citation Subset: AIM; IM |
Affiliation:
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Department of Nuclear Medicine, Academic Medical Centre, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Esophagogastric Junction / drug effects*, physiopathology Gastric Acidity Determination Gastric Emptying / drug effects, physiology Gastroesophageal Reflux / physiopathology Humans Male Nitric Oxide / physiology Peristalsis / drug effects*, physiology Postprandial Period omega-N-Methylarginine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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