Document Detail

Effect of L-NAME on pulmonary arterial pressure, plasma nitric oxide and pulmonary hypertension syndrome morbidity in broilers.
MedLine Citation:
PMID:  12365519     Owner:  NLM     Status:  MEDLINE    
1. Experiments were conducted to evaluate the effect of a synthetic inhibitor of nitric oxide (NO) synthase (L-NAME) on pulmonary arterial pressure (PAP) and pulmonary hypertension syndrome (PHS) morbidity in broilers. 2. In Experiment 1, broilers were infused intravenously with L-NAME, and the mean pulmonary arterial pressure (mean PAP) and plasma NO were measured at 0, 1, 2 and 4 h after the start of infusion. The mean PAP increased and plasma NO was reduced at 1 to 2 h in broilers treated with L-NAME. 3. In Experiment 2, 180 Arbor Acres broilers were evenly divided into three groups: a control group (group C), and two groups exposed to low environmental temperatures and fed a 3, 3, 5-triiodothyronine (T3) supplemented diet alone (group A) or also including 100 ppm L-NAME (group B). 4. The PHS morbidity of group A was higher than for group C but lower than for group B. Plasma endothelin-1 was higher in broilers in groups A and B than in group C. Plasma NO was not significantly lower in broilers of group B when compared with those in group A. 5. The right/total ventricular weight ratio (RV/TV) and mean PAP were higher in groups A and B than in group C, and the RV/TV ratio increased one week earlier in group B than in group A. 6. These results suggest that L-NAME increases broiler PAP by inhibiting the endogenous synthesis of NO, leading to pulmonary hypertension, right ventricular hypertrophy and the increased morbidity of PHS in broilers.
Jinyong Wang; Xiaolong Wang; Ruiping Xiang; Weidong Sun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British poultry science     Volume:  43     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-07     Completed Date:  2003-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  615-20     Citation Subset:  IM    
College of Veterinary Medicine, Nanjing Agricultural University, China.
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MeSH Terms
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Endothelin-1 / blood
Enzyme Inhibitors / pharmacology*
Hypertension, Pulmonary / epidemiology,  etiology,  veterinary*
Injections, Intravenous / veterinary
NG-Nitroarginine Methyl Ester / pharmacology*
Nitric Oxide / blood*
Poultry Diseases / epidemiology*,  etiology
Pulmonary Artery / physiology
Random Allocation
Vascular Resistance / drug effects
Vasodilation / drug effects
Reg. No./Substance:
0/Endothelin-1; 0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester

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