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Effect of L-Arginine Infusion on Glucose Disposal during Exercise in Humans.
MedLine Citation:
PMID:  21311355     Owner:  NLM     Status:  Publisher    
PURPOSE:: We have previously shown that local infusion of a nitric oxide synthase (NOS) inhibitor attenuates increases in leg glucose uptake during exercise in humans. We have also shown that infusion of the NOS substrate, L-arginine (L-Arg), increases glucose clearance, although the mechanisms involved were not determined. A potential mechanism for NO-mediated glucose disposal is via interactions with NOS and the energy sensor AMP-activated protein kinase (AMPK). The aim of this study was to determine the mechanism(s) by which L-Arg infusion increases glucose disposal during exercise in humans by examining total NOS activity and AMPK signaling. METHODS:: Seven males cycled for 120 min at 64 ± 1% VO peak, during which [6,6-2H]glucose tracer was infused. During the final 60 min of exercise either saline alone (Control, CON), or saline containing L-Arg HCl (L-Arg, 30g at 0.5g min) was co-infused in a double-blind, randomized, counter-balanced order. RESULTS:: L-Arg increased the glucose rate of disappearance and glucose clearance rate during exercise, however this was accompanied by a 150% increase in plasma insulin concentration from 65-75 min (P<0.05) that remained significantly elevated until 90 min of exercise. Skeletal muscle AMPK signaling, nNOSμ phosphorylation by AMPK and total NOS activity increased to a similar extent in the two trials. CONCLUSION:: The increase in glucose disposal following L-Arg infusion during exercise is likely due to the significantly higher plasma insulin concentration.
Kelly C Linden; Glenn D Wadley; Andrew P Garnham; Glenn K McConell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-8
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Exercise Physiology and Metabolism Laboratory, Department of Physiology, The University of Melbourne, Victoria, 3010, Australia 2 School of Community Health, Charles Sturt University, Wagga Wagga, New South Wales, 2650, Australia 3 School of Exercise and Nutrition Sciences, Centre for Physical Activity and Nutrition Research, Deakin University, Burwood Victoria, 3125, Australia 4Institute of Sport, Exercise and Active Living and School of Biomedical and Health Sciences, Victoria University, Victoria, 8001, Australia.
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