| Effect of Isoproterenol on Local Contractile Behaviors of Rat Cardiomyocytes Measured by Atomic Force Microscopy. | |
| | |
MedLine Citation:
|
PMID: 22039809 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Inotropic agents induce changes in the contraction amplitude and frequency of cardiomyocytes (CMs). However, it is unknown how local contractions of CMs treated by inotropic agents behave spatiotemporally. In this study, the effect of isoproterenol, a positive inotropic agent, on local contractions of isolated neonatal rat CMs was explored by atomic force microscopy (AFM). We observed that changes in local contraction amplitude of CM in the presence of isoproterenol were heterogeneous; they were unchanged or increased, at different positions, with respect to the amplitude of untreated CMs. Interestingly, spatial heterogeneities of local contraction amplitude of CM in the presence of isoproterenol did not obviously correlate with the local elasticity, indicating that the local contractions were facilitated by cooperative dynamics of the cytoskeletal structure in relatively large regions, rather than those just under AFM indentation. Moreover, local contraction amplitude of CM in the presence of isoproterenol was not proportional to that in the control condition, showing that the former change was no longer additive in local scales. |
| | |
Authors:
|
Takaharu Okajima |
Related Documents
:
|
15740209 - Nuclear magnetic resonance and dielectric investigations of molecular motions in a glas... 3256429 - A non-linear elastic model of contraction of ischaemic segments. 10637109 - Rovibrational energies of triatomic molecules by means of the rayleigh-schrödinger per... 6086059 - Internal dynamics and overall motion of lysozyme studied by fluorescence depolarization... 9438429 - Navigated single-voxel proton spectroscopy of the human liver. 17817129 - Ocean dynamics and acoustic fluctuations in the fram strait marginal ice zone. 14730649 - Predicting long bone loading from cross-sectional geometry. 11541269 - Characteristics of nystagmus and illusion evoked by optokinetic stimuli. 16126849 - Cellular levels of glutamyl-trna reductase and glutamate-1-semialdehyde aminotransferas... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-31 |
Journal Detail:
|
Title: Current pharmaceutical biotechnology Volume: - ISSN: 1873-4316 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-11-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Graduate School of Information Science and Technology, Hokkaido University, Kita-ku N14 W9, Sapporo 060-0814, Japan. okajima@ist.hokudai.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Single Molecular observation of DNA and DNA Complexes by Atomic Force Microscopy.
Next Document: Current Research on Protein-Protein Interactions Among Auxin-Signaling Factors in Regulation of Plan...