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Effect of Ischemic Preconditioning on Lactate Accumulation and Running Performance.
MedLine Citation:
PMID:  22843115     Owner:  NLM     Status:  Publisher    
PURPOSE: Repeated bouts of ischemia followed by reperfusion (i.e. ischemic preconditioning (IPC)), protect against damage after a myocardial infarction. Recent observational data indicate that IPC improves exercise performance. However, no previous study has examined potential underlying mechanisms for this effect of IPC. Therefore, we examined the potential of IPC to improve 5-km running time trial performance and reduce lactate accumulation during an incremental exercise test. METHODS: In a randomised, crossover study, 13 healthy men performed running exercise which was preceded by IPC (4x5 min 220 mmHg bilateral leg occlusion) or a control intervention (C; 4x5 min 20 mmHg bilateral leg occlusion). Participants performed a graded maximal treadmill running test, starting with five 3-min submaximal stages (10-14 km/h), followed by increments of 1 km/h every 2 min to 16 km/h, followed an incline of the treadmill of 2% every 2 min. Blood lactate was examined at each 3 min stage. Following 45 min rest in the supine position, subjects then performed a 5-km running time trial. RESULTS: We found similar sub-maximal gas parameters during running exercise with both interventions. The overall increase in blood lactate during the submaximal stages was 1.07±0.11 mMol.l-1 lower when exercise was preceded with IPC vs. C (P=0.023). The 5-km running time trial was completed in a time that was 34 s faster following IPC vs. C (95%CI: 5 to 64 s, P=0.027). CONCLUSION: IPC improves 5-km time trial performance in healthy male individuals. Moreover, we found that IPC is associated with an attenuated rise in blood lactate concentration at submaximal level during an incremental running test. This could indicate that IPC allows for higher work-rates and thus improves time trial performance.
Tom G Bailey; Helen Jones; Warren Gregson; Greg Atkinson; N Timothy Cable; Dick H J Thijssen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-26
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, United Kingdom 2Health and Social Care Institute, School of Health and Social Care, Teesside University, United Kingdom 3Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
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