Document Detail


The Effect of Iron on Cognitive Development and Function in Infants, Children and Adolescents: A Systematic Review.
MedLine Citation:
PMID:  22142898     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A systematic review was conducted to summarize the evidence currently available from randomized controlled trials (RCTs) concerning the effect of iron intake of infants, children and adolescents on measures of cognitive development and function. The Cochrane Library, MEDLINE and Embase were searched up to and including February 2010. Studies were also identified by checking the bibliographies of the articles retrieved. All RCTs with an adequate control group in which iron supply was provided by natural food sources, fortified foods, formula or supplements to infants, children or adolescents until the age of 18 years were considered for inclusion. No language restrictions were applied. Fourteen studies met the selection criteria. Twelve out of these 14 studies had a high or moderate risk of bias. A large degree of heterogeneity of study populations, iron dosages and outcome measures precluded performing a quantitative meta-analysis. Overall, the studies suggest a modest positive effect of iron supplementation on cognition and psychomotor outcomes in anemic infants and children after supplementation periods of at least 2 months of duration.
Authors:
Maria Hermoso; Vesna Vucic; Christiane Vollhardt; Aleksandra Arsic; Blanca Roman-Viñas; Iris Iglesia-Altaba; Mirjana Gurinovic; Berthold Koletzko
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-02
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  59     ISSN:  1421-9697     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  154-165     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Division of Metabolic and Nutritional Medicine. Dr. von Hauner Children's Hospital, Ludwig Maximilians University of Munich Medical Centre, Munich, Germany.
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