| Effect of intravitreal ranibizumab on corneal endothelium in age-related macular degeneration. | |
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MedLine Citation:
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PMID: 20508510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the effect of intravitreal injection of ranibizumab on the corneal endothelium in patients with choroidal neovascularization in age-related macular degeneration. METHODS: Observational prospective case series study. Fifty-two eyes of 52 consecutive patients (29 men, 23 women; age range, 61-80 years) were evaluated. All participants received monthly intravitreal injections of (0.05 mL, 0.5 mg) ranibizumab for 3 consecutive months; the follow-up period was 6 months. Central corneal specular microscopy was performed before injection and at 7 days and 6 months after the first intravitreal injection. The endothelial cell density, coefficient of variation of cell size, and percentage of hexagonal cells were analyzed, and the central corneal thickness was measured. RESULTS: There were no significant differences in the endothelial cell densities, coefficient of variation of cell sizes, and percentage of hexagonal cells values before injection and at 7 days and 6 months after the first intravitreal ranibizumab injection (P = 0.987, P = 0.822, and P = 0.918, respectively). There was also no significant difference in central corneal thickness measurements before injection and at 7 days and 6 months after the first intravitreal ranibizumab injection (P = 0.325). CONCLUSION: Repeated intravitreal injections of 0.5 mg of ranibizumab do not seem to cause substantial changes in the corneal endothelium at 6 months. |
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Authors:
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Consuelo Pérez-Rico; Javier Benítez-Herreros; María Castro-Rebollo; Yanira Gómez-Sangil; Francisco Germain; María Angeles Montes-Mollón; Miguel Angel Teus |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cornea Volume: 29 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-10-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 849-52 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, University Hospital Principe de Asturias, Spain. cinta.perezrico@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antibodies, Monoclonal / administration & dosage* Cell Count Cell Size Endothelium, Corneal / drug effects*, pathology Female Follow-Up Studies Humans Injections Macular Degeneration / drug therapy* Male Microscopy Middle Aged Prospective Studies Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/ranibizumab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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