Document Detail

The effect of intratympanic methylprednisolone and gentamicin injection on Ménière's disease.
MedLine Citation:
PMID:  23314159     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To compare the efficacy of intratympanic injections of methylprednisolone (ITMP) and intratympanic injections of gentamicin (ITG) to control the symptoms of Ménière's disease and to evaluate their effect on hearing level.
STUDY DESIGN: A historical cohort study.
SETTING: Tertiary referral center.
SUBJECTS AND METHODS: Eighty-nine patients affected by Ménière's disease were included in this study, of whom 47 were treated with ITG and 42 were treated with ITMP. Two periods of follow-up were considered: 0 to 6 months and 6 to 12 months after the intratympanic injections (ITI). Mean outcome measurements consisted of control of vertigo attacks, tinnitus, and aural fullness; pure-tone average (PTA); and speech discrimination score (SDS).
RESULTS: The 2 groups had the same number of vertigo spells per month before ITI (P = .883). Six to 12 months after ITI, 82.9% of the ITG group and 48.1% of the ITMP group achieved complete control of vertigo (P = .004). There was better control of tinnitus and aural fullness with ITG than with ITMP (P ≤ .002). The 2 groups had a statistically significant difference in hearing level before ITI (P ≤ .001). This difference was no longer present 6 to 12 months after ITI (P > .05).
CONCLUSION: Intratympanic injections of gentamicin are more efficient than ITMP in controlling the symptoms of Ménière's disease. The 2 groups ended up without a difference in hearing level after ITI. According to these findings, administrating ITMP to control Ménière's disease seems to be less beneficial than ITG.
Nathalie Gabra; Issam Saliba
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Publication Detail:
Type:  Journal Article     Date:  2013-01-11
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  148     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-28     Completed Date:  2013-06-17     Revised Date:  2013-12-12    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  642-7     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*,  adverse effects
Audiometry, Pure-Tone
Gentamicins / administration & dosage*,  adverse effects
Glucocorticoids / administration & dosage*
Hearing Loss / chemically induced
Meniere Disease / drug therapy*
Methylprednisolone / administration & dosage*
Middle Aged
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 0/Glucocorticoids; X4W7ZR7023/Methylprednisolone
Comment In:
Otolaryngol Head Neck Surg. 2013 Jul;149(1):175   [PMID:  23818540 ]
Laryngorhinootologie. 2013 Nov;92(11):720-1
Otolaryngol Head Neck Surg. 2013 Jul;149(1):175-6   [PMID:  23818541 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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