Document Detail


Effect of Intracoronary Nitroprusside in Preventing No Reflow Phenomenon during Primary Percutaneous Coronary Intervention: A Meta-Analysis.
MedLine Citation:
PMID:  25041036     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Adjunctive therapy with intracoronary nitroprusside (NTP) in primary percutaneous coronary intervention (PPCI) had controversial benefits in patients with ST segment elevation myocardial infarction (STEMI).
OBJECTIVES: To evaluate the effect of intracoronary NTP on no reflow phenomenon (NR) and clinical outcomes in STEMI patients undergoing PPCI.
METHODS: We searched the following databases without language or time limitation in January 2014: PubMed, EMBASE, CENTRAL, ISI Web of Science, and CNKI. Trials compared the effect of intracoronary NTP with control group (placebo or no NTP treatment) on NR in STEMI patients undergoing PPCI enrolled for analyzing.
RESULTS: A total of 7 trials involving 781 patients were included into this meta-analysis. Intracoronary NTP significantly reduced the incidence of thrombolysis in myocardial infarction (TIMI) flow grade (TFG) ≤2 (RR: 0.47, 95% CI: 0.30-0.73, P = 0.001); the corrected TIMI frame count (CTFC) (WMD: -5.28, 95% CI: -6.79 to 3.78, P = 0.000) increased the events of myocardial blush grade (MBG) ≥2 (RR: 1.12, 95% CI: 1.01-1.24, P = 0.038), and reduced the incidence of major adverse cardiac events (MACE) (RR: 0.43, 95% CI: 0.27-0.70, P = 0.001). Although the events of the complete ST segment resolution (STR) did not reach statistical significance, there was a trend indicating improvement in the intracoronary NTP group (RR: 1.143, 95% CI: 0.97-1.34, P = 0.101).
CONCLUSIONS: Intracoronary NTP can significantly reduce the incidence of angiographic NR during PPCI, as well as the incidence of MACE. It seems to be a promising adjunctive therapy for NR during PPCI.
Authors:
Shijie Zhao; Guoxian Qi; Wen Tian; Ling Chen; Yujiao Sun
Related Documents :
1929656 - Protection of ischemic heart from reperfusion injury by myo-inositol hexaphosphate, a n...
10926966 - Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion ...
20959496 - The role of microrna in modulating myocardial ischemia-reperfusion injury.
17240156 - The effects of various leukocyte filtration strategies in cardiac surgery.
22626816 - Improving risk stratification in patients with chest pain: the erlanger hearts(3) score.
23355886 - No evidence for cardiac dysfunction in kif6 mutant mice.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-8
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  -     ISSN:  1540-8183     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014, Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Simultaneous irradiation with different wavelengths of ultraviolet light has synergistic bactericida...
Next Document:  Bayesian design of superiority clinical trials for recurrent events data with applications to bleedi...