| Effect of intensive versus standard blood pressure control on depression and health-related quality of life in type 2 diabetes: the ACCORD trial. | |
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MedLine Citation:
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PMID: 22584134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We tested the hypothesis that intensive (systolic blood pressure [SBP] <120 mmHg) rather than standard (SBP 130-139 mmHg) blood pressure (BP) control improves health-related quality of life (HRQL) in those with type 2 diabetes. RESEARCH DESIGN AND METHODS: Subjects were 1,028 ACCORD (Action to Control Cardiovascular Risk in Diabetes) BP trial HRQL substudy participants who completed baseline and one or more 12-, 36-, or 48-month HRQL evaluations. Multivariable linear regression assessed impact of BP treatment assignment on change in HRQL. RESULTS: Over 4.0 years of follow-up, no significant differences occurred in five of six HRQL measures. Those assigned to intensive (vs. standard) BP control had statistically significant worsening of the Medical Outcomes Study 36-item short-form health survey (SF36) physical component scores (-0.8 vs. -0.2; P = 0.02), but magnitude of change was not clinically significant. Findings persisted across all prespecified subgroups. CONCLUSIONS: Intensive BP control in the ACCORD trial did not have a clinically significant impact, either positive or negative, on depression or patient-reported HRQL. |
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Authors:
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Patrick J O'Connor; K M Venkat Narayan; Roger Anderson; Patricia Feeney; Larry Fine; Mohammed K Ali; Debra L Simmons; Don G Hire; JoAnn M Sperl-Hillen; Lois Anne Katz; Karen L Margolis; Mark D Sullivan |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2012-05-14 |
Journal Detail:
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Title: Diabetes care Volume: 35 ISSN: 1935-5548 ISO Abbreviation: Diabetes Care Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-22 Completed Date: 2012-10-23 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: United States |
Other Details:
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Languages: eng Pagination: 1479-81 Citation Subset: IM |
Affiliation:
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HealthPartners Research Foundation, Minneapolis, MN, USA. patrick.j.oconnor@healthpartners.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects* Depression Diabetes Mellitus, Type 2 / blood, drug therapy, psychology* Humans Hypertension / drug therapy* Quality of Life |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-095183/HC/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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