| The Effect of Insulin on the Intracellular Distribution of 14(R,S)-[(18)F]Fluoro-6-thia-heptadecanoic Acid in Rats. | |
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MedLine Citation:
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PMID: 16645919 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to determine the effect of hyperinsulinemia on myocardial and hepatic distribution and metabolism of 14(R,S)-[(18)F]fluoro-6-thia-heptadecanoic acid ([(18)F]FTHA). PROCEDURES: Mitochondrial retention and intracellular lipid incorporation of [(18)F]FTHA were compared to that of [(14)C]-2-bromopalmitate or [(14)C]palmitate during hyperinsulinemic clamp vs. saline infusion in male Wistar rats. RESULTS: Mitochondrial (18)F activity was increased in the heart (1.7 +/- 0.4 vs. 0.5 +/- 0.1% ID/g, P < 0.05), whereas it was reduced in the liver (1.1 +/- 0.3 vs. 1.8 +/- 0.4% ID/g, P < 0.05) during insulin vs. saline infusion, respectively. Mitochondrial [(14)C]-2-bromopalmitate activity was affected by insulin in a similar way in both tissues. The fractional esterification of [(18)F]FTHA into triglycerides was impaired compared to [(14)C]palmitate in both tissues, and [(18)F]FTHA was insensitive to the shift of esterification of fatty acids into complex lipids in response to insulin. CONCLUSIONS: [(18)F]FTHA is sensitive to insulin-induced modifications of free fatty acid oxidative metabolism in rats but is insensitive to changes in nonoxidative fatty acid metabolism. |
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Authors:
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Ci; Frisch; Lavoie; Germain; Lecomte; van Lier; Bénard; Carpentier |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2006-4-28 |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: - ISSN: 1536-1632 ISO Abbreviation: - Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-4-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Division of Endocrinology, Centre hospitalier universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada, andre.carpentier@usherbrooke.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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