| Effect on infant illness of maternal supplementation with 400 000 IU vs 200 000 IU of vitamin A. | |
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MedLine Citation:
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PMID: 22412025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Postpartum vitamin A supplementation is a strategy used to combat vitamin A deficiency and seems to reduce maternal/infant morbidity and mortality. However, studies have shown that a dose of 200 000 IU (World Health Organization [WHO] protocol) does not seem to provide adequate retinol levels in maternal breast milk, infant serum, and infant tissue. The objective of this study was to compare the effect of postpartum maternal supplementation with 400 000 IU (International Vitamin A Consultative Group protocol) compared with 200 000 IU of vitamin A on infant morbidity. METHODS: This was a randomized controlled, triple-blinded clinical trial conducted at 2 public maternity hospitals in Recife in northeastern Brazil. There were 276 mother-child pairs that were allocated to 2 treatment groups: 400 000 IU or 200 000 IU of vitamin A. They were followed up for >6 months to evaluate infant morbidity. RESULTS: Fever (rate ratio [RR]: 0.92 [95% confidence interval (CI): 0.75-1.14]), diarrhea (RR: 0.96 [95% CI: 0.72-1.28]), otitis (RR: 0.94 [95% CI: 0.48-1.85]), acute respiratory infection (RR: 1.03 [95% CI: 0.88-1.21]), the need for intravenous rehydration (RR: 2.08 [95% CI: 0.64-2.07]), and the use of antibiotic treatment (RR: 0.80 [95% CI: 0.43-1.47]) did not differ significantly between the 2 treatment groups. CONCLUSIONS: Our findings suggest that postpartum maternal supplementation with 400 000 IU of vitamin A does not provide any additional benefits in the reduction of illness in children aged <6 months; therefore, we do not support the proposal to increase the standard vitamin A dose in the existing WHO protocol. |
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Authors:
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Taciana Fernanda dos Santos Fernandes; José Natal Figueiroa; Ilma Kruze Grande de Arruda; Alcides da Silva Diniz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-12 |
Journal Detail:
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Title: Pediatrics Volume: 129 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-04 Completed Date: 2012-06-13 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e960-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition, Universidade Federal de Pernambuco, Brazil. tacimest@hotmail.com |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00742937 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Brazil / epidemiology Diarrhea, Infantile / epidemiology, metabolism, prevention & control* Dietary Supplements* Dose-Response Relationship, Drug Female Humans Infant Infant, Newborn Male Milk, Human / chemistry Morbidity / trends Postpartum Period Treatment Outcome Vitamin A / administration & dosage*, pharmacokinetics Vitamin A Deficiency / drug therapy*, epidemiology Vitamins / administration & dosage, pharmacokinetics Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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