Document Detail

Effect on infant illness of maternal supplementation with 400 000 IU vs 200 000 IU of vitamin A.
MedLine Citation:
PMID:  22412025     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Postpartum vitamin A supplementation is a strategy used to combat vitamin A deficiency and seems to reduce maternal/infant morbidity and mortality. However, studies have shown that a dose of 200 000 IU (World Health Organization [WHO] protocol) does not seem to provide adequate retinol levels in maternal breast milk, infant serum, and infant tissue. The objective of this study was to compare the effect of postpartum maternal supplementation with 400 000 IU (International Vitamin A Consultative Group protocol) compared with 200 000 IU of vitamin A on infant morbidity.
METHODS: This was a randomized controlled, triple-blinded clinical trial conducted at 2 public maternity hospitals in Recife in northeastern Brazil. There were 276 mother-child pairs that were allocated to 2 treatment groups: 400 000 IU or 200 000 IU of vitamin A. They were followed up for >6 months to evaluate infant morbidity.
RESULTS: Fever (rate ratio [RR]: 0.92 [95% confidence interval (CI): 0.75-1.14]), diarrhea (RR: 0.96 [95% CI: 0.72-1.28]), otitis (RR: 0.94 [95% CI: 0.48-1.85]), acute respiratory infection (RR: 1.03 [95% CI: 0.88-1.21]), the need for intravenous rehydration (RR: 2.08 [95% CI: 0.64-2.07]), and the use of antibiotic treatment (RR: 0.80 [95% CI: 0.43-1.47]) did not differ significantly between the 2 treatment groups.
CONCLUSIONS: Our findings suggest that postpartum maternal supplementation with 400 000 IU of vitamin A does not provide any additional benefits in the reduction of illness in children aged <6 months; therefore, we do not support the proposal to increase the standard vitamin A dose in the existing WHO protocol.
Taciana Fernanda dos Santos Fernandes; José Natal Figueiroa; Ilma Kruze Grande de Arruda; Alcides da Silva Diniz
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-12
Journal Detail:
Title:  Pediatrics     Volume:  129     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-04     Completed Date:  2012-06-13     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e960-6     Citation Subset:  AIM; IM    
Department of Nutrition, Universidade Federal de Pernambuco, Brazil.
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MeSH Terms
Administration, Oral
Brazil / epidemiology
Diarrhea, Infantile / epidemiology,  metabolism,  prevention & control*
Dietary Supplements*
Dose-Response Relationship, Drug
Infant, Newborn
Milk, Human / chemistry
Morbidity / trends
Postpartum Period
Treatment Outcome
Vitamin A / administration & dosage*,  pharmacokinetics
Vitamin A Deficiency / drug therapy*,  epidemiology
Vitamins / administration & dosage,  pharmacokinetics
Young Adult
Reg. No./Substance:
0/Vitamins; 11103-57-4/Vitamin A

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