| Effect of indomethacin infused over 30 minutes on cerebral fractional tissue oxygen extraction in preterm newborns with a patent ductus arteriosus. | |
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MedLine Citation:
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PMID: 20389128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A significant patent ductus arteriosus (PDA) is a common finding in the first days of life and, if persistent, is associated with an increased morbidity and mortality in the preterm newborn. OBJECTIVES: Our aim was to investigate, using near-infrared spectroscopy, the effect of indomethacin on the fractional tissue (cerebral) oxygen extraction (FT(c)OE) in a group of preterm newborns undergoing medical treatment for a PDA. METHODS: This is a prospective, observational study. A cohort of 18 preterm newborns (<32 weeks) undergoing treatment for a PDA with indomethacin were monitored continuously for mean arterial blood pressure, arterial oxygen saturation (SpO(2)) and regional cerebral oxygen saturation (r(c)SO(2)). Measurements were started 1 h before and continued for 4 h after the first indomethacin dose. A final measurement (1 h) was made within 24 h of completing the full course. FT(c)OE = [SpO(2) - r(c)SO(2)]/SpO(2) was then calculated. To analyze the data, we chose to average the measurements over 1-hour periods. RESULTS: There was a significant increase in the FT(c)OE (0.06, 95% CI 0.04-0.09, p < 0.001) noticeable within the 1st hour after the start of indomethacin administration, which peaked in the 2nd hour (FT(c)OE increased by 0.08, 95% CI 0.04-0.11, p < 0.001) and lasted for the full 4-hour period measured. CONCLUSION: Indomethacin, infused over 30 min, significantly increased the FT(c)OE in the preterm newborn, the effect lasting at least 4 h. This may represent a protective response to the indomethacin-induced reduction in cerebral blood flow demonstrated by others and warrants further investigation. |
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Authors:
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Paul Keating; Elise Verhagen; Jacorina van Hoften; Henk ter Horst; Arend F Bos |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2010-04-13 |
Journal Detail:
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Title: Neonatology Volume: 98 ISSN: 1661-7819 ISO Abbreviation: Neonatology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101286577 Medline TA: Neonatology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 232-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
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Division of Neonatology, Department of Paediatrics, University Medical Centre Groningen, Groningen, The Netherlands. keatingp69@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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administration & dosage,
pharmacology Cause of Death Cerebrum / drug effects*, metabolism Ductus Arteriosus, Patent / drug therapy*, metabolism, mortality Female Humans Indomethacin / administration & dosage*, pharmacology* Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases / drug therapy*, metabolism, mortality Infusions, Intravenous Male Oxygen / analysis*, metabolism Oxygen Consumption / drug effects, physiology Spectroscopy, Near-Infrared Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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