| Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children. | |
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MedLine Citation:
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PMID: 20413966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The present study was designed to examine the possible changes in body composition, insulin-like growth factor 1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and inflammatory markers of obese children in response to a 2-month program of exercise training combined with dietary restriction. METHODS: Twenty-eight obese children (age 13.2 +/- 0.7 years, body mass index 30.9 +/- 1.3) were randomly assigned to a diet/training group or a control group and were tested two times: once before and once at the end of the experimental period. They performed a progressive cycle ergometer test at each visit. Substrate oxidation was evaluated by indirect calorimetry. Training was individualized at the point when fat oxidation was maximal (Lipox(max)). RESULTS: Diet/training induced a significant decrease in body weight and body fat (after vs. before, p < 0.01). Plasma concentrations of IGF-1, IGFBP-3 and inflammatory markers were significantly decreased after the completion of the program. The diet/training program resulted in an increase in VO(2max)ACSM (24.6 +/- 2.5 to 33.1 +/- 3.1 ml/min/kg, p < 0.001) at the end of the intervention period. CONCLUSION: These data suggest that in the presence of weight loss, exercise training improves inflammatory markers and IGF-1 and IGFBP-3 levels in obese children. |
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Authors:
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Omar Ben Ounis; Mohamed Elloumi; Hassane Zouhal; Emna Makni; Myriam Denguezli; Mohamed Amri; Gérard Lac; Zouhair Tabka |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-04-22 |
Journal Detail:
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Title: Annals of nutrition & metabolism Volume: 56 ISSN: 1421-9697 ISO Abbreviation: Ann. Nutr. Metab. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8105511 Medline TA: Ann Nutr Metab Country: Switzerland |
Other Details:
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Languages: eng Pagination: 260-6 Citation Subset: IM |
Affiliation:
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Laboratoire des adaptations Cardio-circulatoires, Respiratoires, Faculté de Médecine Ibn-El-Jazzar, Sousse,Tunisie. omar_oda @ yahoo.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Anaerobic Threshold / physiology Biological Markers Body Composition Caloric Restriction* Child Cytokines / blood* Exercise Test Female Humans Insulin-Like Growth Factor Binding Protein 3 / blood* Insulin-Like Growth Factor I / analysis, metabolism* Male Obesity / diet therapy, metabolism*, therapy* Physical Fitness / physiology* Skinfold Thickness |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cytokines; 0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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