| Effect of Immunomodulating Medications in Complex Regional Pain Syndrome: A Systematic Review. | |
| | |
MedLine Citation:
|
PMID: 22001668 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND:: Different mechanisms are involved in a complex network of interactions resulting in the painful and impairing disorder, complex regional pain syndrome (CRPS). There is convincing evidence that inflammation plays a pivotal role in the pathophysiology of CRPS. Immunomodulating medication reduces the manifestation of inflammation by acting on the mediators of inflammation. Therefore, as inflammation is involved in the pathophysiology of CRPS, immunomodulating medication in CRPS patients may prove beneficial. OBJECTIVES:: To describe the current empirical evidence for the efficacy of administering the most commonly used immunomodulating medication (ie, glucocorticoids, tumor necrosis factor-α antagonists, thalidomide, bisphosphonates, and immunoglobulins) in CRPS patients. METHODS:: PubMed was searched for original articles that investigated CRPS and the use of one of the abovementioned immunomodulating agents. RESULTS:: The search yielded 39 relevant articles: from these, information on study design, sample size, duration of disease, type and route of medication, primary outcome measures, and results was examined. DISCUSSION:: Theoretically, the use of immunomodulating medication could counteract the ongoing inflammation and might be an important step in improving a disabled hand or foot, leading to further recovery. However, more high-quality intervention studies are needed. |
| | |
Authors:
|
Maaike Dirckx; Dirk L Stronks; George Groeneweg; Frank J P M Huygen |
Related Documents
:
|
8425798 - Pediculosis capitis in istanbul. 19104948 - The forgotten faculty: challenges for ph.d.s in clinical medical school departments. 3745448 - Personality traits of hemophilic boys. 20687298 - Preparing health professionals to provide care to individuals with disabilities. 15154828 - The periodic safety update report as a pharmacovigilance tool. 21389918 - Coronary stenting in patients with medically resistant vasospasm. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-13 |
Journal Detail:
|
Title: The Clinical journal of pain Volume: - ISSN: 1536-5409 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8507389 Medline TA: Clin J Pain Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Erasmus MC, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effective Delivery Styles and Content for Self-management Interventions for Chronic Musculoskeletal ...
Next Document: Quality of Life, Depression, and Anxiety 6 Months After Inpatient Withdrawal in Patients With Medica...