Document Detail

Effect of Hypoglycemic Agents on Ischemic Preconditioning in Patients With Type 2 Diabetes and Symptomatic Coronary Artery Disease.
MedLine Citation:
PMID:  23250803     Owner:  NLM     Status:  Publisher    
OBJECTIVETo assess the effect of two hypoglycemic drugs on ischemic preconditioning (IPC) patients with type 2 diabetes and coronary artery disease (CAD).RESEARCH DESIGN AND METHODSWe performed a prospective study of 96 consecutive patients allocated into two groups: 42 to group repaglinide (R) and 54 to group vilgagliptin (V). All patients underwent two consecutive exercise tests (ET1 and ET2) in phase 1 without drugs. In phase 2, 1 day after ET1 and -2, 2 mg repaglinide three times daily or 50 mg vildagliptin twice daily was given orally to patients in the respective group for 6 days. On the seventh day, 60 min after 6 mg repaglinide or 100 mg vildagliptin, all patients underwent two consecutive exercise tests (ET3 and ET4).RESULTSIn phase 1, IPC was demonstrated by improvement in the time to 1.0 mm ST-segment depression and rate pressure product (RPP). All patients developed ischemia in ET3; however, 83.3% of patients in group R experienced ischemia earlier in ET4, without significant improvement in RPP, indicating the cessation of IPC (P < 0.0001). In group V, only 28% of patients demonstrated IPC cessation, with 72% still having the protective effect (P < 0.0069).CONCLUSIONSRepaglinide eliminated myocardial IPC, probably by its effect on the K(ATP) channel. Vilgagliptin did not damage this protective mechanism in a relevant way in patients with type 2 diabetes and CAD, suggesting a good alternative treatment in this population.
Rosa Maria Rahmi; Augusto Hiroshi Uchida; Paulo Cury Rezende; Eduardo Gomes Lima; Cibele Larrosa Garzillo; Desiderio Favarato; Celia M C Strunz; Myrthes Takiuti; Priscyla Girardi; Whady Hueb; Roberto Kalil Filho; José A F Ramires
Related Documents :
18165563 - Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea an...
23338943 - Effects of dronedarone started rapidly after amiodarone discontinuation.
8659973 - Videothoracoscopy in the treatment of early empyema: an initial experience.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-18
Journal Detail:
Title:  Diabetes care     Volume:  -     ISSN:  1935-5548     ISO Abbreviation:  Diabetes Care     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Atherosclerosis, Heart Institute of the University of São Paulo, São Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Associations Between Diabetes, Leanness, and the Risk of Deaths in the Japanese General Population: ...
Next Document:  Postpregnancy Glycemic Control and Weight Changes in Type 1 Diabetic Women.