Document Detail

Effect of hyperoxic resuscitation on propensity of germinal matrix haemorrhage and cerebral injury.
MedLine Citation:
PMID:  20408959     Owner:  NLM     Status:  MEDLINE    
AIMS: Intraventricular haemorrhage (IVH) and cerebral injury are major neurological disorders of premature infants. The effect of hyperoxic resuscitation on the occurrence of IVH and cerebral injury is elusive. Therefore, we asked whether hyperoxia during neonatal resuscitation increased the incidence and severity of IVH and cerebral injury in premature newborns. METHODS: Premature rabbit pups, delivered by C-section, were sequentially assigned to receive 100%, 40% or 21% oxygen for 15 or 60 min at birth. The pups were treated with intraperitoneal glycerol at 24-h postnatal age to determine the incidence and severity of glycerol-induced IVH. Vascular endothelial growth factor and angiopoietin-2 genes and protein expression, endothelial proliferation as well as free radical levels and antioxidants were assessed in the germinal matrix, white matter and cortex of pups exposed to 100% oxygen and to 21% oxygen. RESULTS: Exposure with 100% oxygen for 1 h did not adversely exacerbate the incidence of glycerol-induced IVH in premature rabbit pups. Compared with room air, 100% oxygen enhanced mRNA expression of both vascular endothelial growth factor and angiopoietin-2 as well as reactive oxygen species levels in the germinal matrix. Hyperoxia did not affect endothelial proliferation, apoptosis or neuronal degeneration in the forebrain. CONCLUSION: Our data suggest that 100% oxygen exposure for 1 h does not increase the risk of IVH or cerebral injury in premature rabbit pups. Although extrapolating rabbit neural developmental data into humans has obvious limitations, we speculate that hyperoxia of short duration at birth in premature infants may not result in major neurological adverse effects.
C O Chua; G Vinukonda; F Hu; N Labinskyy; M T Zia; J Pinto; A Csiszar; Z Ungvari; P Ballabh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-04-14
Journal Detail:
Title:  Neuropathology and applied neurobiology     Volume:  36     ISSN:  1365-2990     ISO Abbreviation:  Neuropathol. Appl. Neurobiol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7609829     Medline TA:  Neuropathol Appl Neurobiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  448-58     Citation Subset:  IM    
Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, New York, USA.
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MeSH Terms
Angiopoietin-2 / genetics
Animals, Newborn
Cell Death / physiology
Cerebral Hemorrhage / epidemiology,  metabolism,  physiopathology*
Disease Models, Animal
Gene Expression / physiology
Glycerol / toxicity
Hyperoxia / epidemiology,  metabolism,  physiopathology*
Oxidative Stress / physiology
Oxygen Inhalation Therapy / adverse effects*,  statistics & numerical data
Premature Birth / epidemiology,  metabolism,  physiopathology*
Resuscitation / adverse effects*,  statistics & numerical data
Risk Factors
Severity of Illness Index
Vascular Endothelial Growth Factor A / genetics
Grant Support
Reg. No./Substance:
0/Angiopoietin-2; 0/Vascular Endothelial Growth Factor A; 56-81-5/Glycerol

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