Document Detail

The effect of hyperbaric oxygen on symptoms after mild traumatic brain injury.
MedLine Citation:
PMID:  23031217     Owner:  NLM     Status:  MEDLINE    
In this single-center, double-blind, randomized, sham-controlled, prospective trial at the U.S. Air Force School of Aerospace Medicine, the effects of 2.4 atmospheres absolute (ATA) hyperbaric oxygen (HBO₂) on post-concussion symptoms in 50 military service members with at least one combat-related, mild traumatic brain injury were examined. Each subject received 30 sessions of either a sham compression (room air at 1.3 ATA) or HBO₂ treatments at 2.4 ATA over an 8-week period. Individual and total symptoms scores on Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®) and composite scores on Post-traumatic Disorder Check List-Military Version (PCL-M) were measured just prior to intervention and 6 weeks after completion of intervention. Difference testing of post-intervention means between the sham-control and HBO₂ group revealed no significant differences on the PCL-M composite score (t=-0.205, p=0.84) or on the ImPACT total score (t=-0.943, p=0.35), demonstrating no significant effect for HBO₂ at 2.4 ATA. PCL-M composite scores and ImPACT total scores for sham-control and HBO(2) groups revealed significant improvement over the course of the study for both the sham-control group (t=3.76, p=0.001) and the HBO₂ group (t=3.90, p=0.001), demonstrating no significant HBO₂ effect. Paired t-test results revealed 10 ImPACT scale scores in the sham-control group improved from pre- to post-testing, whereas two scale scores significantly improved in the HBO₂ group. One PCL-M measure improved from pre- to post-testing in both groups. This study showed that HBO₂ at 2.4 ATA pressure had no effect on post-concussive symptoms after mild TBI.
George Wolf; David Cifu; Laura Baugh; William Carne; Leonardo Profenna
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Publication Detail:
Type:  Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-09
Journal Detail:
Title:  Journal of neurotrauma     Volume:  29     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-13     Revised Date:  2014-01-06    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2606-12     Citation Subset:  IM    
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MeSH Terms
Brain Concussion / psychology,  therapy
Brain Injuries / psychology*,  therapy*
Cognition / physiology
Double-Blind Method
Hyperbaric Oxygenation*
Middle Aged
Prospective Studies
Psychomotor Performance / physiology
Treatment Outcome
Young Adult
Comment In:
J Neurotrauma. 2013 Oct 1;30(19):1681-2   [PMID:  23270538 ]
Diving Hyperb Med. 2013 Sep;43(3):173   [PMID:  24147287 ]
J Neurotrauma. 2013 Dec 1;30(23):1995-9   [PMID:  24004322 ]

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