| Effect of hyper- and hypocapnia on cerebral arterial compliance in normal subjects. | |
| | |
MedLine Citation:
|
PMID: 19888933 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Changes in partial pressure of carbon dioxide (PaCO2) are associated with a decrease in cerebral blood flow (CBF) during hypocapnia and an increase in CBF during hypercapnia. However, the effects of changes in PaCO2 on cerebral arterial compliance (Ca) are unknown. METHODS: We assessed the changes in Ca in 20 normal subjects using monitoring of arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV). Cerebral arterial blood volume (CaBV) was extracted from CBFV. Ca was defined as the ratio between the pulse amplitudes of CaBV (AMP(CaBV) ) and ABP (AMP(ABP) ). All parameters were recorded during normo-, hyper-, and hypocapnia. RESULTS: During hypocapnia, Ca was significantly lower than during normocapnia (.10 ± .04 vs. .17 ± .06; P < .001) secondary to a decrease in AMP(CaBV) (1.3 ± .4 vs. 1.9 ± .5; P < .001) and a concomitant increase in AMP(ABP) (13.8 ± 3.4 vs. 11.6 ± 1.7 mmHg; P < .001). During hypercapnia, there was no change in Ca compared with normocapnia. Ca was inversely correlated with the cerebrovascular resistance during hypo- (R(2) = 0.86; P < .001), and hypercapnia (R(2) = 0.61; P < .001). CONCLUSION: Using a new mathematical model, we have described a reduction of Ca during hypocapnia. Further studies are needed to determine whether Ca may be an independent predictor of outcome in pathological conditions. |
| | |
Authors:
|
Emmanuel Carrera; Dong-Joo Kim; Gianluca Castellani; Christian Zweifel; Peter Smielewski; John D Pickard; Marek Czosnyka |
Related Documents
:
|
18627253 - Changes of cerebral blood flow during the secondary expansion of a cortical contusion a... 20881283 - The different effects of midazolam and propofol sedation on dynamic cerebral autoregula... 20978993 - Coagulation abnormalities in the trauma patient: the role of point-of-care thromboelast... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 21 ISSN: 1552-6569 ISO Abbreviation: J Neuroimaging Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: United States |
Other Details:
|
Languages: eng Pagination: 121-5 Citation Subset: IM |
Copyright Information:
|
Copyright © 2009 by the American Society of Neuroimaging. |
Affiliation:
|
From the Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebral microbleeds are uncommon in ischemic stroke associated with nonvalvular atrial fibrillation...
Next Document: Partial Intra-Aortic Occlusion Improves Perfusion Deficits and Infarct Size Following Focal Cerebral...