Document Detail


The effect of hydrocortisone on neurodevelopmental outcome in premature infants less than 29 weeks' gestation.
MedLine Citation:
PMID:  20139411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of postnatal dexamethasone in premature newborns can be associated with a deleterious neurodevelopmental outcome. The effect of hydrocortisone on developmental outcome in these patients is less clear. We therefore sought to examine the effect of hydrocortisone on early developmental outcome in premature newborns. We retrospectively examined the effect of hydrocortisone on developmental outcome during the first 2 years of life in premature infants <29 weeks' gestation at birth. Even though hydrocortisone was used in infants with a greater risk for poor outcome, its use, unless prolonged >7 days, was generally not associated with a worse developmental outcome or higher rate of referral for early intervention. A short course of hydrocortisone in sick premature newborns does not appear to have a deleterious effect on developmental outcome.
Authors:
Howard Needelman; Arvind Hoskoppal; Arvind Hoskappal; Holly Roberts; Martha Evans; J B Bodensteiner
Publication Detail:
Type:  Journal Article     Date:  2010-02-05
Journal Detail:
Title:  Journal of child neurology     Volume:  25     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-06-29     Revised Date:  2010-07-06    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  448-52     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA. hneedelm@unmc.edu
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Anti-Inflammatory Agents / adverse effects
Brain / drug effects,  growth & development,  physiopathology
Cognition Disorders / chemically induced,  physiopathology
Developmental Disabilities / chemically induced*,  physiopathology
Female
Humans
Hydrocortisone / adverse effects*
Hypotension / drug therapy
Infant, Newborn
Infant, Premature / physiology*
Intensive Care Units, Neonatal / statistics & numerical data*
Lung Diseases / drug therapy
Male
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 50-23-7/Hydrocortisone
Comments/Corrections
Erratum In:
J Child Neurol. 2010 Jul;25(7):928
Note: Hoskappal, Arvind [corrected to Hoskoppal, Arvind]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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