Document Detail


Effect of human skin grafts on whole-body heat loss during exercise heat stress: a case report.
MedLine Citation:
PMID:  23202874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When exposed to heat stress, increases in cutaneous blood flow and sweating in well-healed grafted skin are severely attenuated, which could impair whole-body heat loss if skin grafts cover a large portion of total body surface area (TBSA). It is unknown to what extent whole-body heat loss is impaired when skin grafts cover a significant (eg, >50%) proportion of TBSA. The authors examined whole-body heat exchange during and after 60 min of cycling exercise in the heat (35°C; 25% relative humidity), at a fixed rate of metabolic heat production (~400 W) in a woman (age, 36 years; mass, 78.2 kg) with well-healed (17+ years) skin grafts covering 75% of TBSA. Her responses were compared with two noninjured control subjects. Whole-body evaporative and dry heat exchange were measured by direct calorimetry. While exercising in the same ambient conditions and at the same rate of heat production, relative evaporative heat loss of nongrafted skin in the grafted subject (ie, evaporative heat loss per m) was nearly twice that of the control subjects. However, total rate of evaporative heat loss reached only 59% of the amount required for heat balance in the skin-grafted subject compared with 92 ± 3% in controls. Thus, the increase in core temperature was 2-fold greater for the grafted (1.22°C) vs control (0.61 ± 0.19°C) individuals. This case study demonstrates that a large area of grafted skin greatly diminishes maximum evaporative heat loss during exercise in the heat, making a compensable environment for control subjects uncompensable for skin-grafted individuals.
Authors:
Matthew S Ganio; Daniel Gagnon; Jill Stapleton; Craig G Crandall; Glen P Kenny
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of burn care & research : official publication of the American Burn Association     Volume:  34     ISSN:  1559-0488     ISO Abbreviation:  J Burn Care Res     Publication Date:    2013 Jul-Aug
Date Detail:
Created Date:  2013-07-09     Completed Date:  2014-03-26     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101262774     Medline TA:  J Burn Care Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e263-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Temperature*
Body Temperature Regulation*
Calorimetry
Case-Control Studies
Exercise Test*
Female
Free Tissue Flaps*
Heart Rate
Humans
Grant Support
ID/Acronym/Agency:
GM068865,/GM/NIGMS NIH HHS; R01 GM068865/GM/NIGMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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