| Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. | |
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MedLine Citation:
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PMID: 20617924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cytomegalovirus (CMV) retinitis is a common opportunistic infection among patients with AIDS and still causes visual morbidity despite the wide spread usage of highly active antiretroviral therapy (HAART). The ubiquitous CMV pathogen contains a human interleukin-10 (IL-10) homolog in its genome and utilizes it to evade host immune reactions through an IL-10 receptor mediated immune-suppression pathway. METHODS: Effects of IL-10R1, IL-10 and previously described AIDS restriction gene variants are investigated on the development of CMV retinitis in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) cohort (N = 1284). RESULTS: In European Americans (n = 750), a haplotype carrying an amino acid changing variation in the cytoplasmic domain (S420L) of IL-10R1 can be protective (OR, 0.14; 95% CI, 0.02-0.94; P = .04) against, whereas another haplotype carrying an amino acid changing variation in the extracellular domain (I224V) of IL-10R1 can be more susceptible (OR, 6.21; 95% CI, 1.22- 31.54; P = .03) to CMV retinitis. In African Americans (n = 534), potential effects of IL-10 variants are observed. CONCLUSION: Host genetics may have a role in the occurrence of CMV retinitis in patients infected with HIV. |
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Authors:
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Efe Sezgin; Douglas A Jabs; Sher L Hendrickson; Mark Van Natta; Alexander Zdanov; Richard Alan Lewis; Michael W Smith; Jennifer L Troyer; Stephen J O'Brien; |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 202 ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-16 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 606-13 Citation Subset: AIM; IM |
Affiliation:
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Laboratory of Genomic Diversity, SAIC-Frederick, National Cancer Institute, Frederick, Maryland 21702-1201, USA. sezginef@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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epidemiology,
genetics*,
immunology* Acquired Immunodeficiency Syndrome / complications* Adult African Americans Cytomegalovirus Retinitis / epidemiology, genetics* European Continental Ancestry Group Female Gene Frequency Genetic Predisposition to Disease* Humans Immunity, Innate* Interleukin-10 / genetics Interleukin-10 Receptor alpha Subunit / genetics Longitudinal Studies Male Middle Aged Polymorphism, Genetic United States |
| Grant Support | |
ID/Acronym/Agency:
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HHSN261200800001E//PHS HHS; U10-EY-08052/EY/NEI NIH HHS; U10-EY-08057/EY/NEI NIH HHS; U10-EY-08067/EY/NEI NIH HHS; Z99 CA999999/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-10 Receptor alpha Subunit; 130068-27-8/Interleukin-10 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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