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The Effect of High Intensity Focused Ultrasound on Vascular Endothelial Growth Factor and Microvessel Density in Rabbit V-X2 Hepatocellular Carcinoma Models.
MedLine Citation:
PMID:  22784938     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background/Aims: To study the effect of high intensity focused ultrasound on vascular endothelial growth factor and microvessel density in the rabbit VX-2 hepatocellular carcinoma models. Methodology: Rabbit VX-2 hepatocellular carcinoma models were built by implanting VX-2 tumor cells into the hepatic left lobes of 40 rabbits. After that, the rabbits were randomly divided into four groups: the control group (n=10), the postoperative one-day group (n=10), the postoperative three-day group (n=10) and the postoperative seven-day group (n=10). The expression of VEGF and the MVD in the HCC tissues were observed and measured by immunohistochemistry. Results: After the HIFU treatment, the MVD and the expression of VEGF in the HCC tissues in the postoperative one-day group and post-operative three-day group decreased significantly as compared with the sham-HIFU group (p<0.01). The MVD and the expression of VEGF in the postoperative seven-day group were higher than those of the sham-HIFU group (p<0.05). No obvious difference was shown between the postoperative one-day group and the postoperative three-day group (p>0.05), while the two groups MVD and the expression of VEGF were different with those of the postoperative seven-day group (p<0.01). Conclusions: HIFU causes damage to the microvessels in the HCC tissues, effectively inhibits angiogenesis and reduces blood supply in these tissues.
Authors:
Li-Ping Chen; Ning Li; Hui Ye
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  60     ISSN:  0172-6390     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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