Document Detail

The effect of high gravidity on the carcinogenesis of mammary gland in TA2 mice.
MedLine Citation:
PMID:  20148807     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Spontaneous breast cancer in Tientsin Albinao 2 (TA2) mice, like human pregnancy-associated breast cancer (PABC), often occurs in pregnancy and puerperium, especially in mice with high gravidity. We hypothesized that the dysfunction of cellular immunity caused by the increase of 17beta-estradiol (E2) and progesterone (P) might be one of the reasons for carcinogenesis of mammary gland. METHOD OF STUDY: We investigated the T lymphocyte subsets and the concentration of serum hormone and cytokines in cancer-bearing, pregnant or postpartum TA2 mice using flow cytometry, chemiluminescent immunoassay, and enzyme-linked immunosorbent assay (ELISA), respectively. RESULTS: The number of T lymphocytes and the concentration of E2, P, interleukin-2 (IL-2), IL-4, and interferon-gamma (IFN-gamma) changed with the increase of pregnancy and puerperium. During four pregnancies, elevated E2 and P resulted in a decrease in the number of CD3(+), CD4(+) T lymphocytes, CD4(+)/CD8(+) ratio, and the concentration of IL-2, IL-4, and IFN-gamma. Data in the fourth pregnancy were the closest to those of cancer-bearing mice. CONCLUSION: T lymphocyte subsets and concentration of IL-2, IL-4, and IFN-gamma are affected by E2 and P during multiple pregnancy and delivery to some degree, which may contribute to the genesis of spontaneous breast cancer in TA2 mice.
Xuan Wang; Chun Huang; Baocun Sun; Yanjun Gu; Yanfen Cui; Xiulan Zhao; Yan Li; Shiwu Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-08
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  63     ISSN:  1600-0897     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  396-409     Citation Subset:  IM    
Department of Pathology, Tianjin Cancer Institute and Hospital, Tianjin Medical University, He Xi District, China.
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MeSH Terms
Breast Neoplasms / blood,  etiology,  immunology*,  pathology
Interferon-gamma / blood,  immunology
Interleukin-2 / blood,  immunology
Interleukin-4 / blood,  immunology
T-Lymphocytes / immunology
Reg. No./Substance:
0/Interleukin-2; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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