| Effect of High-Dose Glucocorticosteroid Treatment for Infantile Spasms on Quantitative Bone Parameters Later in Life. | |
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MedLine Citation:
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PMID: 21778189 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study evaluated possible long-term effects of prolonged high-dose glucocorticosteroid administration in infancy. Thirty patients (16 male, 14 female; age 4.8-33 years) who had completed treatment with adrenocorticotropic hormone (ACTH) followed by glucocorticoids for infantile spasms at a tertiary pediatric hospital at least 2 years previously were invited to undergo quantitative bone ultrasound. The mean speed of sound Z score was -1.085 ± 1.079 for the radius and -0.22 ± 1.19 for the tibia on the nondominant side (P = .0022). The difference from the reference mean (0) was statistically significant for the radius (P < .001). There were no significant differences in radial or tibial mean speed of sound Z scores by age (prepubertal versus pubertal/postpubertal). In conclusion, a high percentage of patients treated with glucocorticoids for infantile spasms have a low radial speed of sound Z score later in life. Long-term follow-up can help to prevent and treat impairments in bone density, especially in non-weight-bearing organs. |
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Authors:
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Tal Eidlitz-Markus; Sarah Kivity; Hadassa Goldberg-Stern; Yishai Haimi-Cohen; Avraham Zeharia |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-21 |
Journal Detail:
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Title: Journal of child neurology Volume: - ISSN: 1708-8283 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics E/Ambulatory Day Care Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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