Document Detail

Effect of High Beta-Palmitate Content in Infant Formula on The Intestinal Microbiota of Term Infants: A Double-Blind, Randomized Pilot Study.
MedLine Citation:
PMID:  23201699     Owner:  NLM     Status:  Publisher    
OBJECTIVES:: Palmitic acid (PA) constitutes 17-25% of the human milk fatty acids, and ∼70% is esterified in the sn-2 position of triglycerides (beta-palmitate). In the sn-2 position, PA is not hydrolyzed and thus is efficiently absorbed. The PA in palm oils, commonly used in infant formulas, is esterified in the sn-1 and sn-3 positions. In these positions, PA is hydrolyzed and forms poorly absorbed calcium complexes. This study assessed whether high beta-palmitate in infant formulas affects the intestinal flora. METHODS:: Thirty-six term infants were enrolled: 14 breastfed (BF group) and 22 formula-fed infants who were randomly assigned to receive formula containing high beta-palmitate (HBP group, n = 14), or low beta-palmitate (LBP group, n = 8), where 44% and 14% of the PA was beta-palmitate, respectively. The total amount of PA in the formulas was 19% and 22% in the LBP and HBP groups, respectively. Neither formula contained pre- or probiotics. Stool samples were collected at enrollment and at 6 weeks for the quantification of bacteria. RESULTS:: At 6 weeks, the HBP and BF groups had higher lactobacillus and bifidobacteria counts than the LBP group (P < 0.01). The lactobacillus counts at 6 weeks were not significantly different between the HBP and BF groups. Lactobacillus counts were 1.2 × 10, 1.2 × 10, and 5.6 × 10 CFU/gr for LBP, HBP, and BF groups, respectively. Bifidobacteria counts were 5.1 × 10, 1.2 × 10, and 3.9 × 10 CFU/gr for LBP, HBP, and BF groups, respectively. CONCLUSIONS:: High beta-palmitate formula beneficially affected infant gut microbiota by increasing the lactobacillus and bifidobacteria counts in fecal stools.
Sima Yaron; Dina Shachar; Lee Abramas; Arik Riskin; David Bader; Ita Litmanovitz; Fabiana Bar-Yoseph; Tzafra Cohen; Liora Levi; Yael Lifshitz; Raanan Shamir; Ron Shaoul
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
*Faculty of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa, Israel †Department of Neonatology, Bnai Zion Medical Center affiliated with Rappaport Faculty of Medicine, Technion, Haifa, Israel ‡Neonatology, Meir Medical Center, Kfar Saba Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel §Enzymotec Ltd, Kfar Baruch, Israel ||Institute for Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel ¶Pediatric Gastroenterology Unit, Meyer Children Hospital, Rambam Medical Center, Haifa, Israel.
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