Document Detail

Effect of Herpes simplex virus infection on the trigeminal jaw-opening reflex in guinea pigs.
MedLine Citation:
PMID:  1662108     Owner:  NLM     Status:  MEDLINE    
Herpes simplex virus (HSV) infection induces numerous electrophysiological and microscopic changes in neurons in vitro. To investigate the effect of HSV infection on in vivo neuronal activity, we induced an acute, latent and reactivated HSV infection of the trigeminal ganglia of guinea pigs through orofacial HSV inoculation and studied its effect on the trigeminal jaw-opening reflex of anesthetized guinea pigs. During the acute viral infection period both the threshold for elicitation of the reflex, and the latency to the onset of the reflex response were increased. During the latent viral infection in the trigeminal ganglia, the jaw-opening reflexes in the viral infected animals were not different from those of non-infected control animals. However, reactivation of the latent viral infection in these animals resulted in increases in both the threshold and latency of the jaw-opening reflex. These changes were similar to those found in animals with the acute viral infection. These results indicate that acute or reactivated latent HSV infection of the nervous system results in functional changes in the reflex pathways involving the trigeminal gasserian ganglia and brainstem neurons harboring infectious HSV-1.
J H Lee; L J Goldberg; N H Park
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  560     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-02-11     Completed Date:  1992-02-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
UCLA School of Dentistry 90024.
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MeSH Terms
Antibody Formation
Guinea Pigs
Herpes Simplex / physiopathology*
Jaw / physiopathology*
Lip / injuries
Mesencephalon / microbiology
Reflex / physiology*
Simplexvirus / isolation & purification
Trigeminal Ganglion / microbiology,  physiopathology*
Virus Activation
Wounds and Injuries / immunology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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