Document Detail

The effect of herb-partition moxibustion on Toll-like receptor 4 in rabbit aorta during atherosclerosis.
MedLine Citation:
PMID:  22483185     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To explore the mechanism of Toll-like receptor (TLR4) inhibition in the delay of formation of atherosclerosis by herb-partition moxibustion.
METHOD: Seventy-five rabbits were randomly assigned to one of five groups: blank, atherosclerosis (AS) model, direct moxibustion, herb-partition moxibustion, and drug treatment. With the exception of the blank group, all rabbits were given a high-fat diet in addition to immunologic injury to create the AS model. The experiments were carried out for 16 weeks, at which time the aorta was removed from each rabbit. Immunohistochemical methods were used to detect the gray level of the aortic TLR4 to observe the immunologic competence of its antigens. Fluorescent quantitative polymerase chain reaction was used to detect the expression of TLR4 messenger RNA (mRNA) in the aorta.
RESULTS: The gray-scale value of TLR4 and the TLR4 mRNA expression significantly decreased (p<0.05) in the direct moxibustion, herb-partition moxibustion, and drug treatment groups. Furthermore, the effects of the herb-partition moxibustion and drug treatment were superior to those of the direct moxibustion.
CONCLUSION: Herb-partition moxibustion inhibits aortic TLR4 activity and mRNA expression, showing that herb-partition moxibustion delays the formation of atherosclerosis through the inhibition of TLR4 expression.
Zeng-Hui Yue; Xin-Qun He; Xiao-Rong Chang; Jian-Ling Yuan; Bao-Sheng Yu; Mi Liu; Ling Fu; Liang Zhang; Li-Chao Shang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-10
Journal Detail:
Title:  Journal of acupuncture and meridian studies     Volume:  5     ISSN:  2093-8152     ISO Abbreviation:  J Acupunct Meridian Stud     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-07-31     Revised Date:  2012-08-08    
Medline Journal Info:
Nlm Unique ID:  101490763     Medline TA:  J Acupunct Meridian Stud     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  72-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
College of Acu-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan, China.
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MeSH Terms
Anticholesteremic Agents / therapeutic use
Atherosclerosis / genetics,  metabolism,  prevention & control*
Diet, High-Fat
Disease Models, Animal
Heptanoic Acids / therapeutic use
Moxibustion / methods*
Plant Preparations*
Polymerase Chain Reaction
Pyrroles / therapeutic use
RNA, Messenger / metabolism
Random Allocation
Toll-Like Receptor 4 / antagonists & inhibitors*,  genetics,  immunology
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Antigens; 0/Heptanoic Acids; 0/Plant Preparations; 0/Pyrroles; 0/RNA, Messenger; 0/Toll-Like Receptor 4; 110862-48-1/atorvastatin

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