| Effect of Helicobacter pylori eradication on gastric mucosal phospholipid content and its fatty acid composition. | |
| | |
MedLine Citation:
|
PMID: 11339417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND AIMS: Whether Helicobacter pylori eradication alters gastric mucosal phospholipid contents and their fatty acid composition remains unclear. The aim of the present study was to clarify the effect of H. pylori eradication on gastric mucosal phosphatidylcholine (PC) content and its fatty acid composition. METHODS: Endoscopic biopsy specimens were taken from the antrum and body of each of 19 asymtomatic male volunteers for detection of H. pylori, histopathological assessment of gastritis, phospholipid determination and fatty acid analysis. All the subjects with H. pylori infection were treated with eradication therapy. Endoscopy and tissue sampling were repeated again 1 and 6 months after all treatment. RESULTS: In eight subjects, H. pylori infection was evident and was successfully eradicated. Pretreatment degrees of lymphocytes and plasma cells (inflammation) and polymorphonuclear neutrophils (activity) were greater in H. pylori-positive subjects compared with H. pylori-negative subjects (P<0.001), whereas the degree of inflammation decreased (P<0.001), and neutrophils had completely disappeared at 6 months after eradication. Moreover, the gastric mucosal PC contents at the antrum and body were unchanged within 1 month after cessation of treatment, but increased at 6 months after eradication (P<0.05). At 6 months after cessation of treatment, H. pylori-eradicated subjects had an increase (+30% at antrum, +18% at body) in linoleic acid composition and a decrease (-37%, -43%) in arachidonic acid composition of PC at the antrum and body, respectively. CONCLUSIONS: These findings suggest that H. pylori eradication reduces the production of various eicosanoids, resulting in the normalization of gastric mucosal PC content and its fatty acid composition, which may consequently cause the gastric mucosal hydrophobicity to be normalized. |
| | |
Authors:
|
T Orihara; H Wakabayashi; A Nakaya; K Fukuta; S Makimoto; K Naganuma; A Entani; A Watanabe |
Related Documents
:
|
12722147 - Duodenal ulcer prevalence: research into the nature of possible protective dietary lipids. 199147 - Endocrine influences on ulceration and regeneration in the alkali-burned cornea. 8477607 - Successful treatment of pyoderma gangrenosum with topical 5-aminosalicylic acid. 10751237 - Gastric acid suppression does not promote clostridial diarrhoea in the elderly. 9147867 - Viability of cryptosporidium parvum during ensilage of perennial ryegrass. 16978827 - Microbial metabolism of caffeic acid and its esters chlorogenic and caftaric acids by h... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of gastroenterology and hepatology Volume: 16 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2001 Mar |
Date Detail:
|
Created Date: 2001-05-07 Completed Date: 2001-10-11 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
|
Languages: eng Pagination: 269-75 Citation Subset: IM |
Affiliation:
|
Third Department of Internal Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anti-Bacterial Agents* Arachidonic Acid / metabolism Drug Therapy, Combination / therapeutic use* Fatty Acids / metabolism* Gastric Mucosa / metabolism*, pathology Gastritis / microbiology, pathology Helicobacter Infections / drug therapy*, metabolism*, pathology Helicobacter pylori* / isolation & purification Humans Linoleic Acid / metabolism Male Middle Aged Phosphatidylcholines / metabolism Stomach / microbiology |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Fatty Acids; 0/Phosphatidylcholines; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A randomized controlled comparison of three quadruple therapy regimens in a population with low Heli...
Next Document: Comparison of clinical, serological and histological findings between non-ulcer dyspepsia patients w...