| Effect of HR (O-(beta-hydroxyethyl)-rutosides) on the impaired venous function of young females taking oral contraceptives. A strain gauge plethysmographic and clinical open controlled study. | |
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MedLine Citation:
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PMID: 7008418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3 groups of women were studied to determine the relationship of venous disease to use of oral contraceptives (OCs) by strain gauge plethysmography. Group A consisted of 14 women taking OCs and having symptoms of venous disorders in their legs but no evident venous disease. Group B was 12 women also taking OCs but with no leg symptoms. And Group C was 14 control women not taking OCs and with no leg symptoms. Plethysmography indicated that in Group A venous capacitance and venous distensibility were significantly higher, whereas venous tone was significantly lower than in controls. Also, Group B showed a significant but slightly inferior impairment of these parameters. No differences in venous pressure or in venous outflow were seen in the 3 groups. The effects of HR (O-)beta-hydroxyethyl)-rutoside), a flavonoid, were investigated and showed that the drug provoked a significant decrease in venous capacitance with increase in venous tone and decrease in venous distensibility in Group A patients. Findings were evident after 1 month of treatment (2 gm/day by os). Leg symptoms also improved significantly. Therefore use of this agent may prevent pill-induced venous damage. |
Authors:
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S Forconi; M Guerrini; S Pecchi; R Cappelli; F Bruni |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: VASA. Zeitschrift für Gefässkrankheiten Volume: 9 ISSN: 0301-1526 ISO Abbreviation: VASA Publication Date: 1980 |
Date Detail:
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Created Date: 1981-04-24 Completed Date: 1981-04-24 Revised Date: 2012-10-19 |
Medline Journal Info:
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Nlm Unique ID: 0317051 Medline TA: Vasa Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 324-30 Citation Subset: IM; J |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Clinical Trials as Topic Contraceptives, Oral / adverse effects* Female Humans Hydroxyethylrutoside / therapeutic use* Plethysmography Rutin / analogs & derivatives* Venous Insufficiency / chemically induced, physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 0/Hydroxyethylrutoside; 153-18-4/Rutin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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