Document Detail

Effect of HR (O-(beta-hydroxyethyl)-rutosides) on the impaired venous function of young females taking oral contraceptives. A strain gauge plethysmographic and clinical open controlled study.
MedLine Citation:
PMID:  7008418     Owner:  NLM     Status:  MEDLINE    
3 groups of women were studied to determine the relationship of venous disease to use of oral contraceptives (OCs) by strain gauge plethysmography. Group A consisted of 14 women taking OCs and having symptoms of venous disorders in their legs but no evident venous disease. Group B was 12 women also taking OCs but with no leg symptoms. And Group C was 14 control women not taking OCs and with no leg symptoms. Plethysmography indicated that in Group A venous capacitance and venous distensibility were significantly higher, whereas venous tone was significantly lower than in controls. Also, Group B showed a significant but slightly inferior impairment of these parameters. No differences in venous pressure or in venous outflow were seen in the 3 groups. The effects of HR (O-)beta-hydroxyethyl)-rutoside), a flavonoid, were investigated and showed that the drug provoked a significant decrease in venous capacitance with increase in venous tone and decrease in venous distensibility in Group A patients. Findings were evident after 1 month of treatment (2 gm/day by os). Leg symptoms also improved significantly. Therefore use of this agent may prevent pill-induced venous damage.
S Forconi; M Guerrini; S Pecchi; R Cappelli; F Bruni
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  9     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  324-30     Citation Subset:  IM; J    
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MeSH Terms
Clinical Trials as Topic
Contraceptives, Oral / adverse effects*
Hydroxyethylrutoside / therapeutic use*
Rutin / analogs & derivatives*
Venous Insufficiency / chemically induced,  physiopathology,  prevention & control*
Reg. No./Substance:
0/Contraceptives, Oral; 0/Hydroxyethylrutoside; 153-18-4/Rutin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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