Document Detail

Effect of HMR 3339, a novel selective estrogen receptor modulator, on C-reactive protein levels in healthy postmenopausal women.
MedLine Citation:
PMID:  15518626     Owner:  NLM     Status:  MEDLINE    
We investigated the 12-week effects of 3 doses of HMR 3339, a novel selective estrogen receptor modulator, in comparison with raloxifene and placebo, on plasma concentrations of C-reactive protein in 96 healthy postmenopausal women. A dose-dependent reduction in C-reactive protein was observed, the largest reduction with HMR 3339 50 mg.
Tatjana E Vogelvang; Velja Mijatovic; Peter Kenemans; Casper G Schalkwijk; Marius J van der Mooren
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  94     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-02     Completed Date:  2005-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1205-8     Citation Subset:  AIM; IM    
Project Aging Women and the Institute for Cardiovascular Research-Vrije Universiteit (ICaR-VU), Amsterdam, The Netherlands.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / drug effects*,  metabolism*
Dose-Response Relationship, Drug
Estradiol / administration & dosage,  analogs & derivatives*,  therapeutic use*
Hormone Replacement Therapy
Middle Aged
Postmenopause / drug effects*,  metabolism*
Raloxifene / administration & dosage,  therapeutic use
Selective Estrogen Receptor Modulators / administration & dosage,  therapeutic use*
Time Factors
Treatment Outcome
Women's Health
Reg. No./Substance:
0/Biological Markers; 0/HMR 3339; 0/Selective Estrogen Receptor Modulators; 50-28-2/Estradiol; 84449-90-1/Raloxifene; 9007-41-4/C-Reactive Protein

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