Document Detail

Effect of H1 receptor stimulation on coronary artery diameter in patients with variant angina: comparison with effect of acetylcholine.
MedLine Citation:
PMID:  1991889     Owner:  NLM     Status:  MEDLINE    
It has been suggested that histamine is involved in the pathogenesis of coronary spasm but its exact role remains unclear. H1 receptor stimulation of the coronary artery was performed with a selective intracoronary infusion of histamine (2 micrograms/min) in 21 patients with variant angina after blockade of the H2 receptor with cimetidine (25 mg/kg) and its effect on the coronary artery diameter was examined. Intracoronary injection of acetylcholine was also performed in 19 of the 21 patients. Ergonovine (0.2 mg) was intravenously administered in one patient. The coronary artery diameter was measured with cinevideodensitometric analysis. A mean plasma histamine concentration in the coronary sinus increased from 4 x 10(-9) to 7 x 10(-8) M 5 min after histamine infusion into the left coronary artery (n = 18). Coronary spasm was induced in 6 patients (29%) with histamine, in 18 (95%) with acetylcholine and in 1 with ergonovine. The effect of histamine on the luminal diameter was analyzed at the site of spasm in the 26 coronary arteries in which spasm was induced by acetylcholine or ergonovine. Of the 20 coronary arteries with a normal arteriogram or a fixed stenosis less than or equal to 50% of luminal diameter, histamine decreased the diameter in 4, increased it in 14 (70%) and caused no change in 2; of the 6 coronary arteries with a fixed stenosis greater than or equal to 75%, histamine decreased the diameter in 5 and increased it in 1. In the coronary arteries in which spasm was not induced by either acetylcholine or ergonovine, histamine increased the diameter, especially in those without advanced atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS)
K Okumura; H Yasue; K Matsuyama; K Matsuyama; Y Morikami; H Ogawa; K Obata
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  17     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-45     Citation Subset:  AIM; IM    
Division of Cardiology, Kumamoto University Medical School, Japan.
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MeSH Terms
Acetylcholine / diagnostic use*
Angina Pectoris, Variant / etiology*
Coronary Vasospasm / chemically induced*,  physiopathology
Coronary Vessels / drug effects*
Ergonovine / diagnostic use
Histamine / diagnostic use*,  physiology
Middle Aged
Receptors, Histamine H1 / drug effects*,  physiology
Vasodilation / drug effects
Reg. No./Substance:
0/Receptors, Histamine H1; 51-45-6/Histamine; 51-84-3/Acetylcholine; 60-79-7/Ergonovine
Comment In:
J Am Coll Cardiol. 1991 Feb;17(2):346-7   [PMID:  1671398 ]

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