| The effect of GH replacement therapy on different fat compartments: a whole-body magnetic resonance imaging study. | |
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MedLine Citation:
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PMID: 20930061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Patients with GH deficiency (GHD) are insulin resistant with an increase in visceral fat mass (FM). Whether this holds true when sedentary control subjects (CS) are matched for waist has not been documented. GH replacement therapy (GHRT) results in a decrease in FM. Whether the decrease in FM is mainly related to a reduction in visceral FM remains to be proven. The aim was to separately assess visceral and subcutaneous FM in relation to insulin resistance (IR) in GHD patients before and after GHRT and in sedentary CS. METHODS: Ten patients with GHD were investigated before and 6 months after GHRT. Sedentary CS matched for age, gender, body mass index, and waist were assessed. Exercise capacity was measured as VO(2max) using an incremental work load on a treadmill. Visceral and subcutaneous FM were measured using whole-body magnetic resonance imaging and IR by the homeostasis model assessment of IR (HOMA-IR) index. RESULTS: GHD patients had a non-significantly lower VO(2max) but did not have increased subcutaneous and visceral FM compared with CS. GHRT resulted in a similar relative decrease in subcutaneous and visceral FM. Compared with CS, GHD patients showed a lower HOMA-IR. GHRT tended to increase HOMA-IR. CONCLUSION: Matching for waist and separate assessment of visceral and subcutaneous FM may be critical in the evaluation of body composition and IR in GHD patients before and after GHRT. |
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Authors:
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A Egger; T Buehler; C Boesch; P Diem; C Stettler; E R Christ |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-07 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 164 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 23-9 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Clinical Nutrition, Inselspital, Bern University Hospital Department of Clinical Research, University of Bern, CH-3010 Bern, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Composition* Body Mass Index Case-Control Studies Female Human Growth Hormone / administration & dosage*, deficiency* Humans Intra-Abdominal Fat / pathology* Magnetic Resonance Imaging* Male Middle Aged Prospective Studies Sedentary Lifestyle Subcutaneous Fat / pathology* Waist Circumference |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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