| Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growth. | |
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MedLine Citation:
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PMID: 19005979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Currants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Messinia) as well as methanol extracts obtained from Sultanas cultivated in the island of Crete as to inhibition of cell proliferation, induction of apoptosis, and inhibition of inflammation. All extracts from 500 microg dried raisins studied suppressed cell proliferation, significantly those obtained from Sultanas from Crete and currants from Nemea. Flow cytometric analysis of Annexin-V labeled cells indicated that Cretan Sultana, Nemea, and Messinia currants at 500 microg dried product/ml medium significantly induced cell death. All extracts from 500 microg dried raisins statistically decreased protein and mRNA levels of ICAM-1 in TNF-alpha stimulated cells. Measurement of IL-8 protein levels and quantification for IL-8 mRNA showed no significant decrease. These results indicate that the methanol extracts from currants, rich in phenolic compounds, exhibit cancer preventive efficacy by limiting cell proliferation, inducing cell death, and suppressing ICAM-1 levels in AGS cells. |
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Authors:
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Andriana C Kaliora; Aggeliki M Kountouri; Vaios T Karathanos; Lemonica Koumbi; Nikolaos G Papadopoulos; Nikolaos K Andrikopoulos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nutrition and cancer Volume: 60 ISSN: 1532-7914 ISO Abbreviation: Nutr Cancer Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-13 Completed Date: 2009-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 792-9 Citation Subset: IM |
Affiliation:
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Department of Science of Dietetics & Nutrition, Harokopion University of Athens, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticarcinogenic Agents
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pharmacology* Apoptosis / drug effects Cell Line, Tumor Cell Proliferation / drug effects Flavonoids / analysis Humans Intercellular Adhesion Molecule-1 / analysis, genetics Interleukin-8 / analysis, genetics Phenols / analysis Plant Extracts / pharmacology* RNA, Messenger / analysis Stomach Neoplasms / pathology, prevention & control* Tumor Necrosis Factor-alpha / pharmacology Vitis* / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anticarcinogenic Agents; 0/Flavonoids; 0/Interleukin-8; 0/Phenols; 0/Plant Extracts; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 0/polyphenols; 126547-89-5/Intercellular Adhesion Molecule-1 |
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