Document Detail

Effect of Greek raisins (Vitis vinifera L.) from different origins on gastric cancer cell growth.
MedLine Citation:
PMID:  19005979     Owner:  NLM     Status:  MEDLINE    
Currants and Sultanas (Vitis vinifera L.) are dried vine products produced in Greece and used broadly in the Mediterranean diet. We aimed to investigate the gastric cancer preventive activity of methanol extracts obtained from currants from three different origins in Greece (Vostizza, Nemea, and Messinia) as well as methanol extracts obtained from Sultanas cultivated in the island of Crete as to inhibition of cell proliferation, induction of apoptosis, and inhibition of inflammation. All extracts from 500 microg dried raisins studied suppressed cell proliferation, significantly those obtained from Sultanas from Crete and currants from Nemea. Flow cytometric analysis of Annexin-V labeled cells indicated that Cretan Sultana, Nemea, and Messinia currants at 500 microg dried product/ml medium significantly induced cell death. All extracts from 500 microg dried raisins statistically decreased protein and mRNA levels of ICAM-1 in TNF-alpha stimulated cells. Measurement of IL-8 protein levels and quantification for IL-8 mRNA showed no significant decrease. These results indicate that the methanol extracts from currants, rich in phenolic compounds, exhibit cancer preventive efficacy by limiting cell proliferation, inducing cell death, and suppressing ICAM-1 levels in AGS cells.
Andriana C Kaliora; Aggeliki M Kountouri; Vaios T Karathanos; Lemonica Koumbi; Nikolaos G Papadopoulos; Nikolaos K Andrikopoulos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  60     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2008  
Date Detail:
Created Date:  2008-11-13     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  792-9     Citation Subset:  IM    
Department of Science of Dietetics & Nutrition, Harokopion University of Athens, Athens, Greece.
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MeSH Terms
Anticarcinogenic Agents / pharmacology*
Apoptosis / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Flavonoids / analysis
Intercellular Adhesion Molecule-1 / analysis,  genetics
Interleukin-8 / analysis,  genetics
Phenols / analysis
Plant Extracts / pharmacology*
RNA, Messenger / analysis
Stomach Neoplasms / pathology,  prevention & control*
Tumor Necrosis Factor-alpha / pharmacology
Vitis* / chemistry
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Flavonoids; 0/Interleukin-8; 0/Phenols; 0/Plant Extracts; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 0/polyphenols; 126547-89-5/Intercellular Adhesion Molecule-1

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