| The Effect of Gemfibrozil, Niacin and Cholestyramine Combination Therapy on Metabolic Syndrome in the Armed Forces Regression Study. | |
| | |
MedLine Citation:
|
PMID: 21358314 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION:: Metabolic syndrome is a powerful predictor of cardiovascular events independent of overt diabetes. Dietary restriction and weight loss modify metabolic syndrome components. This study addresses whether combination pharmacologic therapy focused on dyslipidemia provides additional benefit. METHODS:: This study examines the effect of 1 year of gemfibrozil, niacin and cholestyramine therapy on a baseline of aggressive dietary and lifestyle intervention in 143 clinically stable, nondiabetic patients with coronary disease, randomized into a double-blind, placebo-controlled trial. RESULTS:: Cohort characteristics included age 63 ± 7 years, 92% men, 43% with previous myocardial infarction, systolic blood pressure 139 ± 17 mm Hg, triglycerides 168 ± 81 mg/dL and high-density lipoprotein cholesterol 34 ± 6 mg/dL. The mean number of metabolic syndrome components decreased from 2.2 ± 0.9 to 1.5 ± 1.1, P < 0.001, and metabolic syndrome prevalence decreased from 38% to 18% (P < 0.001) for the entire cohort. In the lifestyle intervention and placebo group, the mean number of metabolic syndrome components decreased from 2.2 ± 0.9 to 1.9 ± 1.1 (P = 0.01), and prevalence of metabolic syndrome decreased from 44% to 30% (P = 0.15). A far more marked change was observed with lifestyle intervention and pharmacologic therapy: abnormal metabolic components decreased from 2.2 ± 0.9 to 1.0 ± 1.0 (P < 0.001), and prevalence of metabolic syndrome decreased from 32% to 6% (P < 0.001). CONCLUSIONS:: The combination of gemfibrozil, niacin and cholestyramine has profound, beneficial effects on the components of metabolic syndrome. These benefits are additive to those seen with aggressive diet and lifestyle modification. |
| | |
Authors:
|
Richard A Krasuski; Ganesh P Devendra; George Cater; Edwin J Whitney |
Related Documents
:
|
18302254 - Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review. 3873204 - Laboratory evaluation of the adrenogenital syndrome. 3716964 - Biopsychosocial approach to premenstrual syndrome. 21291104 - Prevalence of the metabolic syndrome in jamaican adults and its relationship to income ... 15148644 - Hemophagocytic syndrome caused by fulminant ulcerative colitis and cytomegalovirus infe... 20062724 - Gorlin-goltz syndrome: incidental finding on routine ct scan following car accident. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: - ISSN: 1538-2990 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Division of Clinical Cardiology (rak, gpd, gc), Department of CV Medicine, The Cleveland Clinic, Cleveland, Ohio; and Heart and Vascular Institute of San Antonio (ejw), San Antonio, Texas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Severe Hypernatremia Correction Rate and Mortality in Hospitalized Patients.
Next Document: Angiotensin II Upregulation of Cardiomyocyte Adiponectin Production Is Nitric Oxide/Cyclic GMP Depen...