| Effect of Gd-EOB-DTPA on T2-weighted and diffusion-weighted images for the diagnosis of hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 20578029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effect of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) for the diagnosis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: The phantom signal intensity was measured. We also evaluated 72 patients including 30 patients with HCC. T2WI and DWI were obtained before and then 4 and 20 min after injecting the contrast medium. The signal to noise ratio (SNR), contrast to noise ratio (CNR), and apparent diffusion coefficient (ADC) were calculated in the tumor and liver parenchyma. RESULTS: The phantom signal intensity increased on T2WI at a concentration of contrast medium less than 0.2 mmol/L but decreased when the concentration exceeded 0.4 mmol/L. SNR of the liver parenchyma on T2WI was significantly different between before and 4 min after injecting the contrast medium, while there were no significant differences between before and 4 and 20 min after injection. On T2WI, SNR, and CNR of HCC showed no significant differences at any time. SNR, CNR, and ADC of the liver parenchyma and tumor on DWI also showed no significant differences at any time. CONCLUSION: It is acceptable to perform T2WI and DWI after injection of Gd-EOB-DTPA for the diagnosis of HCC. |
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Authors:
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Kazuhiro Saito; Yoichi Araki; Jinho Park; Ryo Metoki; Hiroaki Katsuyama; Ryota Nishio; Dai Kakizaki; Fuminori Moriyasu; Koichi Tokuuye |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 229-34 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Tokyo Medical University, Tokyo, Japan. saito-k@tokyo-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Carcinoma, Hepatocellular / diagnosis* Contrast Media / diagnostic use* Diagnosis, Differential Diffusion Magnetic Resonance Imaging / methods* Dose-Response Relationship, Drug Female Gadolinium DTPA / diagnostic use* Humans Image Enhancement / methods* Imaging, Three-Dimensional / methods Liver / pathology Liver Neoplasms / diagnosis* Male Observer Variation Phantoms, Imaging Prospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/gadolinium ethoxybenzyl DTPA; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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