Document Detail

The Effect of Garlic Tablet on Pro-inflammatory Cytokines in Postmenopausal Osteoporotic Women: A Randomized Controlled Clinical Trial.
MedLine Citation:
PMID:  23039014     Owner:  NLM     Status:  Publisher    
ABSTRACT Introduction: Menopause is one of the important causes of osteoporosis which results from estrogen deficiency. In addition, some clinical and experimental evidence indicates that there is an association between increasing pro-inflammatory cytokine activity and postmenopausal bone loss. The purpose of this study was to determine the effect of garlic tablet on pro-inflammatory cytokines in postmenopausal osteoporotic women. Methods: The present study was a double-blind randomized controlled clinical trial in Yazd conducted during November 2009 until July 2010. The sample included 44 postmenopausal osteoporotic women who were randomly assigned into two groups: the garlic group (GG) and the placebo group (PG). Participants in GG took two garlic tablets daily for 1 month and the participants in PG took placebo tablets in the same manner. Serum interlukin-1, interlukin-6, and tumor necrosis factor alpha (TNF-α) were measured using the ELISA method before and after the intervention. Also, 24-hour dietary recall was recorded for estimation of daily intake of some nutrients. Data were analyzed using SPSS software. Results: There was no statistically significant difference between interlukin-1 and interlukin-6 in the two groups before and after the intervention. The mean of TNF-α did not show any statistically significant difference between the two groups before and after the intervention, but it was significantly reduced by about 47% (from 31.14±50.53 to 19.33±22.19 ng/ml, P-value = 0.05) in GG after the intervention, However, no significant difference was seen in PG. Conclusions: The present study produced some evidence for an immunomodulatory effect of garlic, as well as the modulation of cytokine production.
Hassan Mozaffari-Khosravi; Hamideh-Al-Sadat Hesabgar; Mohammad-Bagher Owlia; Hossein Hadinedoushan; Kazem Barzegar; Mohammad Hossein Fllahzadeh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-8
Journal Detail:
Title:  Journal of dietary supplements     Volume:  -     ISSN:  1939-022X     ISO Abbreviation:  J Diet Suppl     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101249830     Medline TA:  J Diet Suppl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Nutrition, Faculty of Health, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.
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