Document Detail

Effect of Garcinia mangostana on inflammation caused by Propionibacterium acnes.
MedLine Citation:
PMID:  17644272     Owner:  NLM     Status:  MEDLINE    
The present study was aimed to investigate the activity of Thai medicinal plants on inflammation caused by Propionibacterium acnes in terms of free radical scavenging and cytokine reducing properties. P. acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. Antioxidant activity was determined by DPPH scavenging and NBT reduction assay. The result showed that Garcinia mangostana possessed the most significant antioxidant activity and reduced reactive oxygen species production. Houttuynia cordata, Eupatorium odoratum, and Senna alata had a moderate antioxidant effect. In addition, Garcinia mangostana extracts could reduce the TNF-alpha production as determined by ELISA. Garcinia mangostana was highly effective in scavenging free radicals and was able to suppress the production of pro-inflammatory cytokines. This study has identified the promising source of anti-inflammatory agent which could be useful in treatment of acne vulgaris.
Mullika Traidej Chomnawang; Suvimol Surassmo; Veena S Nukoolkarn; Wandee Gritsanapan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-02
Journal Detail:
Title:  Fitoterapia     Volume:  78     ISSN:  0367-326X     ISO Abbreviation:  Fitoterapia     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-11-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  401-8     Citation Subset:  IM    
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Rachathevi, Bangkok, Thailand.
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MeSH Terms
Acne Vulgaris / drug therapy*,  microbiology,  pathology
Antioxidants / administration & dosage,  chemistry,  pharmacology*,  therapeutic use
Biphenyl Compounds
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Garcinia mangostana*
Inflammation / drug therapy,  microbiology,  pathology
Leukocytes, Mononuclear / metabolism
Microbial Sensitivity Tests
Nitroblue Tetrazolium / chemistry
Picrates / chemistry
Plant Extracts / administration & dosage,  chemistry,  pharmacology*,  therapeutic use
Propionibacterium acnes / pathogenicity*
Tumor Necrosis Factor-alpha / biosynthesis*,  drug effects
Reg. No./Substance:
0/Antioxidants; 0/Biphenyl Compounds; 0/Picrates; 0/Plant Extracts; 0/Tumor Necrosis Factor-alpha; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 298-83-9/Nitroblue Tetrazolium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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