| Effect of GABA-transminase inhibition on rectal temperature in mice. | |
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MedLine Citation:
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PMID: 263549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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gamma-Acetylenic GABA (amino-4-hex-5-ynoic acid) and gamma-vinyl GABA (amino-4-hex-5-enoic acid), two catalytic irreversible inhibitors of GABA-transaminase, produce marked sustained elevations in brain GABA concentrations. Associated with these biochemical changes is a decrease in the rectal temperature of mice. This hypothermia can be reversed by increasing ambient temperature. The results suggest GABA plays an important role in mammalian central thermoregulation. |
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Authors:
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P J Schechter; Y Tranier |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 6 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1984-06-21 Completed Date: 1984-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 667-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobutyrate Transaminase
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antagonists & inhibitors* Alkynes Aminocaproic Acids / pharmacology* Animals Body Temperature / drug effects* Brain Chemistry / drug effects Mice Mice, Inbred Strains Rectum Vigabatrin gamma-Aminobutyric Acid / analysis |
| Chemical | |
Reg. No./Substance:
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0/Alkynes; 0/Aminocaproic Acids; 56-12-2/gamma-Aminobutyric Acid; 57659-38-8/4-amino-5-hexynoic acid; 60643-86-9/Vigabatrin; EC 2.6.1.19/4-Aminobutyrate Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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